Synthesis, Structure and Properties of Novel S-Substituted BIS-1,2,4-Triazoles

Yevhen KARPUN

doi:https://doi.org/10.52794/hujpharm.973420

Article Details

Synthesis, Structure and Properties of Novel S-Substituted BIS-1,2,4-Triazoles

Authors:

Yevhen KARPUN

Publisher:

Hacettepe University

Main Topics:

Pharmacology and therapeutics

Journal:

Hacettepe University Journal of the Faculty of Pharmacy 2021 Vol.41 Issue 3, pp.150-161

Document Type:

Article

Publication Date:

8/2021

Document Language:

English

Document ID (Org No.):

2000454284

Frequency:

Quarterly

eISSN:

2458-8806

DOI:

https://doi.org/10.52794/hujpharm.973420

Abstract:

 

The aim of the work was to describe the method of combining two 1,2,4-triazole systems in a molecule, the alkylation reaction of the thiol group to obtain the previ- ously undiscovered S-derivatives of 1,2,4-triazole and the fragmentation pathway of the substances under hard ionization using gas chromatography-mass spectrom- etry. The structures of the synthesized compounds were confirmed by elemental analysis, 1H and 13C NMR spectroscopy and GC-MS analysis. The characteristic signals for S-alkyl residues were observed in the region typical for aliphatic com- pounds. The fragmentation of molecules was represented by the gradual cleavage of radicals and the opening of the second 1,2,4-triazole heterocycle.

 

Özet. Çalışmanın amacı, bir molekülde iki 1,2,4-triazol sistemini birleştirme yöntemini, daha önce keşfedilmemiş 1,2,4-triazolün S-türevlerini elde etmek için tiyol grubunun alkilasyon reaksiyonunu ve gaz kromatografisi-kütle spektrometrisi kullanılarak sert iyonizasyon altındaki maddelerin parçalanma yolu. Sentezlenen bileşiklerin yapıları element analizi, 1H ve 13C NMR spektroskopisi ve GC-MS analizi ile doğrulandı. S-alkil tortuları için karakteristik sinyaller, alifatik bileşikler için tipik olan bölgede gözlendi. Moleküllerin parçalanması, radikallerin kademeli olarak bölünmesi ve ikinci 1,2,4-triazol heterosiklinin açılması ile temsil edildi.

Article Details

Synthesis, Structure and Properties of Novel S-Substituted BIS-1,2,4-Triazoles

Authors: Yevhen KARPUN

Publisher: Hacettepe University

Main Topics: Pharmacology and therapeutics

Journal: Hacettepe University Journal of the Faculty of Pharmacy 2021 Vol.41 Issue 3, pp.150-161

Document Type: Article

Publication Date: 8/2021

Document Language: English

Document ID (Org No.): 2000454284

Frequency: Quarterly

eISSN: 2458-8806

DOI: https://doi.org/10.52794/hujpharm.973420

Issues

Authors:

Yevhen KARPUN

Publisher:

Hacettepe University

Main Topics:

Pharmacology and therapeutics

Journal:

Hacettepe University Journal of the Faculty of Pharmacy 2021 Vol.41 Issue 3, pp.150-161

Document Type:

Article

Publication Date:

8/2021

Document Language:

English

Document ID (Org No.):

2000454284

Frequency:

Quarterly

eISSN:

2458-8806

DOI:

https://doi.org/10.52794/hujpharm.973420