Comparative Study on the Effect of Silver Nanoparticles versus Silver Sulfadiazine in Diabetic Wound Healing in Albino Rat : A Histological Study

Heba Mohamed Fawzy; Amany El Shawarby; Nagwa Kostandy Kalleny; Safaa M. Shaker

Article Details

Comparative Study on the Effect of Silver Nanoparticles versus Silver Sulfadiazine in Diabetic Wound Healing in Albino Rat : A Histological Study

Authors:

Heba Mohamed Fawzy | Amany El Shawarby | Nagwa Kostandy Kalleny | Safaa M. Shaker

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2018 Vol.73 Issue 2, pp.6042-6051

Document Type:

Article

Publication Date:

7/2018

Document Language:

English

Document ID (Org No.):

128950

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: the impairment of wound healing in the diabetic patients is an important clinical problem affecting millions of patients worldwide. This significant health care problem still lacks effective therapy. The ideal wound dressing is resistant to external forces and pathogens. It reduces patient discomfort and achieves good cosmetic results.Aim of the work: this study aimed to compare the effect of silver nanoparticles versus silver sulfadiazine on diabetic wound healing in the adult albino rat.Material and Methods: twenty adult female albino rats were included in this study. The animals were categorized into four groups, 5 rats each: group I (control).Group II (untreated diabetic wound): diabetic rats that left untreated for 15 days of wound excision. GroupIII: diabetic rats in which silver sulfadiazine cream was applied on the wound daily for 15 days after thin skin excision. GroupIV: diabetic rats in which nanosilver-ointment was applied on the wound daily for 15 days after thin skin excision.At the end of the experiment, the specimens were taken and processed for histological and immunohistochemical studies. Morphometric and statistical studies were carried out.Results: examination of thin skin sections of nanosilver treated group revealed continuous epidermis with differentiated keratinocytes with proliferating basal layer .The dermis showed increased collagen deposition ,decreased p53 and increased VEGF expression compared to SSD treated group. Conclusion: silver nanoparticles could be more effective than silver sulfadiazine in treatment of the diabetic wound.

Article Details

Comparative Study on the Effect of Silver Nanoparticles versus Silver Sulfadiazine in Diabetic Wound Healing in Albino Rat : A Histological Study

Authors:

Heba Mohamed Fawzy | Amany El Shawarby | Nagwa Kostandy Kalleny | Safaa M. Shaker

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2018 Vol.73 Issue 2, pp.6042-6051

Document Type:

Article

Publication Date:

7/2018

Document Language:

English

Document ID (Org No.):

128950

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

HISTOLOGY

IMMUNOHISTOCHEMISTRY

WOUND HEALING

DIABETES

RATS

Silver Nanoparticles

Silver Sulfadiazine

Diabetes

Wound

Issues

Article Details

Authors: Heba Mohamed Fawzy | Amany El Shawarby | Nagwa Kostandy Kalleny | Safaa M. Shaker

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2018 Vol.73 Issue 2, pp.6042-6051

Document Type: Article

Publication Date: 7/2018

Document Language: English

Document ID (Org No.): 128950

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Heba Mohamed Fawzy | Amany El Shawarby | Nagwa Kostandy Kalleny | Safaa M. Shaker

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2018 Vol.73 Issue 2, pp.6042-6051

Document Type:

Article

Publication Date:

7/2018

Document Language:

English

Document ID (Org No.):

128950

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002