Linear Growth Arrest Without Weight Gain Due to Overuse of Topical Clobetasol

Zahra Razavi; Milad Sanginabadi

doi:10.5001/omj.2014.118

Article Details

Linear Growth Arrest Without Weight Gain Due to Overuse of Topical Clobetasol

Authors:

Zahra Razavi | Milad Sanginabadi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2014 Vol.29 Issue 6, pp.454-457

Document Type:

Article

Publication Date:

11/2014

Document Language:

English

Document ID (Org No.):

56508

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2014.118

Descriptors:

Abstract:

 Prolonged potent topical glucocorticoid therapy in infants can cause iatrogenic Cushing’s syndrome. This case highlights the rarity of poor weight gain in iatrogenic Cushing’s syndrome. A 17-month-old boy was referred to outpatients pediatric endocrine clinic for evaluation of growth failure. On presentation his weight was 9.7kg (5th percentile) and height was 72cm (-3.6 SD below mean for age and sex). Systemic examination revealed grossly moon-like face, hypertrichosis and thin skin in the genital area. His mother reported using local clobetasol for the previous seven months for his diaper dermatitis. Baseline plasma cortisol was low (0.3ng/ml, normal range: 60 to 280ng/ml). During standard dose of synthetic adrenocorticotropic hormone test, the peak cortisol level was 0.4ng/ml (N>180ng/ml) and was consistent with hypothalamic–pituitary–adrenal axis suppression. The patient’s clinical presentation and laboratory investigations confirmed the diagnosis of secondary adrenal insufficiency and iatrogenic Cushing’s syndrome. He was treated successfully by discontinuing use of clobetasol. His appearance and growth returned to normal within two months. Morning cortisol was 101.2ng/ml after stopping the oral physiologic dose of hydrocortisone. Our case differed from other reports of iatrogenic Cushing’s syndrome by presenting in poor weight gain rather than obesity.

Article Details

Linear Growth Arrest Without Weight Gain Due to Overuse of Topical Clobetasol

Authors:

Zahra Razavi | Milad Sanginabadi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2014 Vol.29 Issue 6, pp.454-457

Document Type:

Article

Publication Date:

11/2014

Document Language:

English

Document ID (Org No.):

56508

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2014.118

Descriptors:

ENDOCRINE DISEASES

CUSHING'S SYNDROME

SIDE EFFECTS

WEIGHT GAIN

DRUGS

THERAPY

INFANTS

Issues

Article Details

Authors: Zahra Razavi | Milad Sanginabadi

Publisher: Oman Medical Specialty Board

Main Topics: Medicine

Journal: Oman Medical Journal 2014 Vol.29 Issue 6, pp.454-457

Document Type: Article

Publication Date: 11/2014

Document Language: English

Document ID (Org No.): 56508

Frequency: Bi-Monthly

eISSN: 20705204

pISSN: 1999768X

DOI: 10.5001/omj.2014.118

Descriptors:

Issues

Authors:

Zahra Razavi | Milad Sanginabadi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2014 Vol.29 Issue 6, pp.454-457

Document Type:

Article

Publication Date:

11/2014

Document Language:

English

Document ID (Org No.):

56508

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2014.118