Factors Affecting Serum Vitamin D Level in Epilepsy

N.A.

Article Details

Factors Affecting Serum Vitamin D Level in Epilepsy

Authors:

N.A.

Publisher:

Dicle University

Main Topics:

Tıp Eğitimi

Journal:

Dicle Tıp Dergisi Vol.50 Issue 2, pp.156-164

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001290501

pISSN:

1300-2945

Keywords:

Abstract:

 Objective: Our aim was evaluate the relationship between 25-Hydroxyvitamin D 25OHD and old and new generation anti-seizure drugs ASDs, seizure type and seizure frequency in epilepsy patients. Method: A total of 96 individuals aged 18 years and older with epilepsy were included in this study who were followed up in the SBU Adana City Training and Research Hospital Epilepsy outpatient clinic between January 1, 2020 and November 1, 2022 and met the inclusion criteria. Patients were grouped by age, gender, seizure type, frequency, and ASDs usage according to their relationship with cytochrome P450 enzymes. Complete blood count, kidney functions, serum ASD levels and calcium, magnesium, phosphate and parathormone levels, season when 25OHD were measured, and sun exposure time was also obtained from patient file scans. Results: 55.2 of the patients were women and the mean age was 32.5612.90 Min:18 Max:71. 25OHD level was found to be deficient or insufficient in 95.8 of the patients. The 25OHD level was statistically significantly lower in patients with generalized and complex partial epilepsy who were exposed to the sun for less than one hour per week compared to the focal type and those exposed to the sun for more than one hour per week. p0.05 Conclusion: 25OHD levels should be closely monitored in patients with epilepsy who use ASD for a long time it should be aimed to provide effective seizure control and a positive effect on bone metabolism with appropriate replacement therapy.

 Objective: Our aim was evaluate the relationship between 25-Hydroxyvitamin D 25OHD and old and new generation anti-seizure drugs ASDs, seizure type and seizure frequency in epilepsy patients. Method: A total of 96 individuals aged 18 years and older with epilepsy were included in this study who were followed up in the SBU Adana City Training and Research Hospital Epilepsy outpatient clinic between January 1, 2020 and November 1, 2022 and met the inclusion criteria. Patients were grouped by age, gender, seizure type, frequency, and ASDs usage according to their relationship with cytochrome P450 enzymes. Complete blood count, kidney functions, serum ASD levels and calcium, magnesium, phosphate and parathormone levels, season when 25OHD were measured, and sun exposure time was also obtained from patient file scans. Results: 55.2 of the patients were women and the mean age was 32.5612.90 Min:18 Max:71. 25OHD level was found to be deficient or insufficient in 95.8 of the patients. The 25OHD level was statistically significantly lower in patients with generalized and complex partial epilepsy who were exposed to the sun for less than one hour per week compared to the focal type and those exposed to the sun for more than one hour per week. p0.05 Conclusion: 25OHD levels should be closely monitored in patients with epilepsy who use ASD for a long time it should be aimed to provide effective seizure control and a positive effect on bone metabolism with appropriate replacement therapy.

 Objective: Our aim was evaluate the relationship between 25-Hydroxyvitamin D 25OHD and old and new generation anti-seizure drugs ASDs, seizure type and seizure frequency in epilepsy patients. Method: A total of 96 individuals aged 18 years and older with epilepsy were included in this study who were followed up in the SBU Adana City Training and Research Hospital Epilepsy outpatient clinic between January 1, 2020 and November 1, 2022 and met the inclusion criteria. Patients were grouped by age, gender, seizure type, frequency, and ASDs usage according to their relationship with cytochrome P450 enzymes. Complete blood count, kidney functions, serum ASD levels and calcium, magnesium, phosphate and parathormone levels, season when 25OHD were measured, and sun exposure time was also obtained from patient file scans. Results: 55.2 of the patients were women and the mean age was 32.5612.90 Min:18 Max:71. 25OHD level was found to be deficient or insufficient in 95.8 of the patients. The 25OHD level was statistically significantly lower in patients with generalized and complex partial epilepsy who were exposed to the sun for less than one hour per week compared to the focal type and those exposed to the sun for more than one hour per week. p0.05 Conclusion: 25OHD levels should be closely monitored in patients with epilepsy who use ASD for a long time it should be aimed to provide effective seizure control and a positive effect on bone metabolism with appropriate replacement therapy.

 Objective: Our aim was evaluate the relationship between 25-Hydroxyvitamin D 25OHD and old and new generation anti-seizure drugs ASDs, seizure type and seizure frequency in epilepsy patients. Method: A total of 96 individuals aged 18 years and older with epilepsy were included in this study who were followed up in the SBU Adana City Training and Research Hospital Epilepsy outpatient clinic between January 1, 2020 and November 1, 2022 and met the inclusion criteria. Patients were grouped by age, gender, seizure type, frequency, and ASDs usage according to their relationship with cytochrome P450 enzymes. Complete blood count, kidney functions, serum ASD levels and calcium, magnesium, phosphate and parathormone levels, season when 25OHD were measured, and sun exposure time was also obtained from patient file scans. Results: 55.2 of the patients were women and the mean age was 32.5612.90 Min:18 Max:71. 25OHD level was found to be deficient or insufficient in 95.8 of the patients. The 25OHD level was statistically significantly lower in patients with generalized and complex partial epilepsy who were exposed to the sun for less than one hour per week compared to the focal type and those exposed to the sun for more than one hour per week. p0.05 Conclusion: 25OHD levels should be closely monitored in patients with epilepsy who use ASD for a long time it should be aimed to provide effective seizure control and a positive effect on bone metabolism with appropriate replacement therapy.

Article Details

Factors Affecting Serum Vitamin D Level in Epilepsy

Authors:

N.A.

Publisher:

Dicle University

Main Topics:

Tıp Eğitimi

Journal:

Dicle Tıp Dergisi Vol.50 Issue 2, pp.156-164

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001290501

pISSN:

1300-2945

Epilepsy

seizure

anti-seizure medication

vitamin 25(OH)D

Issues

Article Details

Factors Affecting Serum Vitamin D Level in Epilepsy

Authors: N.A.

Publisher: Dicle University

Main Topics: Tıp Eğitimi

Journal: Dicle Tıp Dergisi Vol.50 Issue 2, pp.156-164

Document Type: Article

Publication Date: 12/2023

Document Language: English

Document ID (Org No.): 2001290501

pISSN: 1300-2945

Epilepsy

seizure

anti-seizure medication

vitamin 25(OH)D

Issues

Authors:

N.A.

Publisher:

Dicle University

Main Topics:

Tıp Eğitimi

Journal:

Dicle Tıp Dergisi Vol.50 Issue 2, pp.156-164

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001290501

pISSN:

1300-2945