Probable Atrophied Islet Cells Revival after Treatment with Olea Eurpaea and Lepidium Sativum Extracts in Alloxan Induced Diabetic Mice

Amr M. Awad; Ahmed A. Tayel; Ahmed I. Ibrahim

doi:10.12816/0009469

Article Details

Probable Atrophied Islet Cells Revival after Treatment with Olea Eurpaea and Lepidium Sativum Extracts in Alloxan Induced Diabetic Mice

Authors:

Amr M. Awad | Ahmed A. Tayel | Ahmed I. Ibrahim

Publisher:

Al-Qassim University

Main Topics:

Medicine

Journal:

Journal of Agricultural and Veterinary Sciences 2014 vol.7 Issue 2, pp.139-148

Document Type:

Article

Publication Date:

7/2014

Document Language:

English

Document ID (Org No.):

59404

Frequency:

Bi-Annual

pISSN:

16584015

DOI:

10.12816/0009469

Descriptors:

Keywords:

Abstract:

 The simulation of atrophied islet cells of the pancreas, by extracts of Olea eurpaea leaves and Lepidium sativum seeds, in alloxan-induced diabetic mice was evaluated. 35 mice were divided into four groups; Group 1 was given only feed and distilled water throughout the period of the experiment. In Group 3, mice were pretreated with the extract of O. eurpaea leaves for 15 days, whereas Group 4 mice were pretreated with the extract of L. sativum seeds for 15 days. Diabetes was induced in mice of Groups 2, 3, and 4 with 150 mg/kg of body weight of alloxan monohydrate. Group 2 mice were used as the experimental positive control. The results showed a significantly high blood glucose level in Group 2 mice indicating the diabetic state. The blood glucose level of mice in Group 3 and 4 reduced when compared with the value of Group 2 mice. The histopathological examination revealed atrophied islet of Langerhans in Group 2 mice. Groups 3 and 4 showed remarkable reviving islet cells. The results suggest that the crude extract of O. eurpaea leaves and L. sativum seeds has a protective effect against alloxan induced pancreatic damage .This study indicates worth anti-diabetic activity of this plants and recommends the use of herbal drugs for diabetic mellitus treatment .

Article Details

Probable Atrophied Islet Cells Revival after Treatment with Olea Eurpaea and Lepidium Sativum Extracts in Alloxan Induced Diabetic Mice

Authors:

Amr M. Awad | Ahmed A. Tayel | Ahmed I. Ibrahim

Publisher:

Al-Qassim University

Main Topics:

Medicine

Journal:

Journal of Agricultural and Veterinary Sciences 2014 vol.7 Issue 2, pp.139-148

Document Type:

Article

Publication Date:

7/2014

Document Language:

English

Document ID (Org No.):

59404

Frequency:

Bi-Annual

pISSN:

16584015

DOI:

10.12816/0009469

Descriptors:

DIABETES

HISTOPATHOLOGY

LESIONS

PLANT EXTRACTS

THERAPY

LABORATORY ANIMALS

Diabetes mellitus

Plant extracts

Glucose level

Histopathology

β- cell

Lesions

Issues

Article Details

Authors: Amr M. Awad | Ahmed A. Tayel | Ahmed I. Ibrahim

Publisher: Al-Qassim University

Main Topics: Medicine

Journal: Journal of Agricultural and Veterinary Sciences 2014 vol.7 Issue 2, pp.139-148

Document Type: Article

Publication Date: 7/2014

Document Language: English

Document ID (Org No.): 59404

Frequency: Bi-Annual

pISSN: 16584015

DOI: 10.12816/0009469

Descriptors:

Issues

Authors:

Amr M. Awad | Ahmed A. Tayel | Ahmed I. Ibrahim

Publisher:

Al-Qassim University

Main Topics:

Medicine

Journal:

Journal of Agricultural and Veterinary Sciences 2014 vol.7 Issue 2, pp.139-148

Document Type:

Article

Publication Date:

7/2014

Document Language:

English

Document ID (Org No.):

59404

Frequency:

Bi-Annual

pISSN:

16584015

DOI:

10.12816/0009469