Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Dilek Nartop; Elvan Hasanoğlu Özkan; Hatice Öğütçü; Nurdan Kurnaz Yetim

Article Details

Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Authors:

Dilek Nartop | Elvan Hasanoğlu Özkan | Hatice Öğütçü | Nurdan Kurnaz Yetim

Publisher:

Duzce University

Main Topics:

Fiziksel Kimya (Diğer)

Journal:

Düzce Üniversitesi Bilim ve Teknoloji Dergisi Vol.12 Issue 3, pp.1389-1397

Document Type:

Article

Publication Date:

7/2024

Document Language:

English

Document ID (Org No.):

2001323950

pISSN:

2148-2446

Keywords:

Abstract:

 In the present work, novel heterocyclic thiazole-based thiosemicarbazone AgI complexes Hc1, Hc2, Hc3 were obtained using the template method. The structures of synthesized thiosemicarbazone compounds were determined by some spectroscopic techniques element analysis, infrared spectra IR, thermogravimetric analysis TGA, organic elemental analysis, and magnetic susceptibility measurements. The biological activities of novel heterocyclic thiazole-based thiosemicarbazone AgI complexes werev screenedv in vitro against selected disease-causing pathogens Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonellav typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026, Candidav albicans Y-1200-NIH were as potential antimicrobial agents. It was determined that the thiazole-based thiosemicarbazone AgI complexes exhibited high or moderate antibacterial and antifungal activity.

 In the present work, novel heterocyclic thiazole-based thiosemicarbazone AgI complexes Hc1, Hc2, Hc3 were obtained using the template method. The structures of synthesized thiosemicarbazone compounds were determined by some spectroscopic techniques element analysis, infrared spectra IR, thermogravimetric analysis TGA, organic elemental analysis, and magnetic susceptibility measurements. The biological activities of novel heterocyclic thiazole-based thiosemicarbazone AgI complexes werev screenedv in vitro against selected disease-causing pathogens Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonellav typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026, Candidav albicans Y-1200-NIH were as potential antimicrobial agents. It was determined that the thiazole-based thiosemicarbazone AgI complexes exhibited high or moderate antibacterial and antifungal activity.

 In the present work, novel heterocyclic thiazole-based thiosemicarbazone AgI complexes Hc1, Hc2, Hc3 were obtained using the template method. The structures of synthesized thiosemicarbazone compounds were determined by some spectroscopic techniques element analysis, infrared spectra IR, thermogravimetric analysis TGA, organic elemental analysis, and magnetic susceptibility measurements. The biological activities of novel heterocyclic thiazole-based thiosemicarbazone AgI complexes werev screenedv in vitro against selected disease-causing pathogens Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonellav typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026, Candidav albicans Y-1200-NIH were as potential antimicrobial agents. It was determined that the thiazole-based thiosemicarbazone AgI complexes exhibited high or moderate antibacterial and antifungal activity.

 Sunulan bu çalışmada, yeni heterosiklik tiyazol bazlı tiyosemikarbazon AgI kompleksleri Hc1, Hc2, Hc3 template yöntem ile elde edildi. Sentezlenen tiyosemikarbazon bileşiklerinin yapıları bazı spektroskopik teknikler element analizi, infrared spektra IR, termogravimetrik analiz TGA, organic elemental analiz, ve magnetik duyarlılık ölçümleri ile karakterize edildi. Yeni heterosiklik tiyazol bazlı tiyosemikarbazon AgI komplekslerinin biyolojik aktiviteleri potansiyel antimikrobiyal ajanlar olarak seçilmiş hastalık yapıcı patojenlere Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteusv vulgaris RSKK96026, Candida albicans Y-1200-NIH karşı in vitro olarak incelendi.

Article Details

Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Authors:

Dilek Nartop | Elvan Hasanoğlu Özkan | Hatice Öğütçü | Nurdan Kurnaz Yetim

Publisher:

Duzce University

Main Topics:

Fiziksel Kimya (Diğer)

Journal:

Düzce Üniversitesi Bilim ve Teknoloji Dergisi Vol.12 Issue 3, pp.1389-1397

Document Type:

Article

Publication Date:

7/2024

Document Language:

English

Document ID (Org No.):

2001323950

pISSN:

2148-2446

Ag(I) complex

Thiazole

Thiosemicarbazone

Biological activityAg(I) kompleksi

Tiyazol

Tiyosemikarbazon

Biyolojik aktivite

Issues

Article Details

Authors: Dilek Nartop | Elvan Hasanoğlu Özkan | Hatice Öğütçü | Nurdan Kurnaz Yetim

Publisher: Duzce University

Main Topics: Fiziksel Kimya (Diğer)

Journal: Düzce Üniversitesi Bilim ve Teknoloji Dergisi Vol.12 Issue 3, pp.1389-1397

Document Type: Article

Publication Date: 7/2024

Document Language: English

Document ID (Org No.): 2001323950

pISSN: 2148-2446

Issues

Authors:

Dilek Nartop | Elvan Hasanoğlu Özkan | Hatice Öğütçü | Nurdan Kurnaz Yetim

Publisher:

Duzce University

Main Topics:

Fiziksel Kimya (Diğer)

Journal:

Düzce Üniversitesi Bilim ve Teknoloji Dergisi Vol.12 Issue 3, pp.1389-1397

Document Type:

Article

Publication Date:

7/2024

Document Language:

English

Document ID (Org No.):

2001323950

pISSN:

2148-2446