Study of the Role of Insulin Resistance as a Risk Factor in Hcv Related Hepatocellular Carcinoma

Amany Ahmad Ibrahim; Mostafa Hamed Abdel Aleem; Heba Mohamed Abdella; Amir Helmy

doi:10.12816/0010856

Article Details

Study of the Role of Insulin Resistance as a Risk Factor in Hcv Related Hepatocellular Carcinoma

Authors:

Amany Ahmad Ibrahim | Mostafa Hamed Abdel Aleem | Heba Mohamed Abdella | Amir Helmy

Publisher:

The Egyptian Society of Parasitology

Main Topics:

Medicine

Journal:

Journal of the Egyptian Society of Parasitology 2015 Vol.45 Issue 1, pp.107-113

Document Type:

Article

Publication Date:

4/2015

Document Language:

English

Document ID (Org No.):

62939

Frequency:

Tri-Annual

pISSN:

11100583

DOI:

10.12816/0010856

Descriptors:

Keywords:

Abstract:

 Chronic HCV infection causes hepatic cirrhosis and approximately 10%-20% of cirrhoticpatients may develop hepatocellular carcinoma within 5 years. Diabetes mellitus is associatedwith a 2-4-fold increase in the risk of HCC. Insulin resistance (IR) emerged as a risk factorfor a variety of cancers, including endometrial and breast and various gastrointestinal cancers.The role of IR in the development of HCC associated with chronic HCV infection has notbeen established. This study elucidated the role of insulin resistance assessed by the homeostasismodel (HOMA-IR) in development of hepatocellular carcinoma associated with chronichepatitis C infection. The study included 3 groups: GI: 100 newly diagnosed cases of HCVrelated hepatocellular carcinoma GII: 60 patients with HCV related chronic liver disease. Fortyhealthy persons as a control group (GIII). All groups were subjected to full history taking,physical examination, laboratory investigations abdominal ultrasonography and Triphasic C.Texamination. In addition to Calculation of Body mass Index, Measurement of fasting bloodinsulin and glucose, Calculation of insulin resistance using HOMA-IR. The results showedthat fasting insulin and HOMA-IR were significantly higher among HCC group than HCVgroup & control group. Also, fasting insulin and HOMA-IR were significantly higher in HCVgroup than control group. HOMA-IR above 3.7, insulin above 9μU/L & DM were consideredindependent predictors of HCC.

Article Details

Study of the Role of Insulin Resistance as a Risk Factor in Hcv Related Hepatocellular Carcinoma

Authors:

Amany Ahmad Ibrahim | Mostafa Hamed Abdel Aleem | Heba Mohamed Abdella | Amir Helmy

Publisher:

The Egyptian Society of Parasitology

Main Topics:

Medicine

Journal:

Journal of the Egyptian Society of Parasitology 2015 Vol.45 Issue 1, pp.107-113

Document Type:

Article

Publication Date:

4/2015

Document Language:

English

Document ID (Org No.):

62939

Frequency:

Tri-Annual

pISSN:

11100583

DOI:

10.12816/0010856

Descriptors:

MEDICAL SCIENCES

CANCER

INFECTIOUS HEPATITIS

HEPATOCELLULAR CARCINOMA

INSULIN

DISEASE CONTROL

PATIENTS

Hepatocellular Carcinoma

Diabetes Mellitus

Insulin Resistance

Issues

Article Details

Authors: Amany Ahmad Ibrahim | Mostafa Hamed Abdel Aleem | Heba Mohamed Abdella | Amir Helmy

Publisher: The Egyptian Society of Parasitology

Main Topics: Medicine

Journal: Journal of the Egyptian Society of Parasitology 2015 Vol.45 Issue 1, pp.107-113

Document Type: Article

Publication Date: 4/2015

Document Language: English

Document ID (Org No.): 62939

Frequency: Tri-Annual

pISSN: 11100583

DOI: 10.12816/0010856

Descriptors:

Issues

Authors:

Amany Ahmad Ibrahim | Mostafa Hamed Abdel Aleem | Heba Mohamed Abdella | Amir Helmy

Publisher:

The Egyptian Society of Parasitology

Main Topics:

Medicine

Journal:

Journal of the Egyptian Society of Parasitology 2015 Vol.45 Issue 1, pp.107-113

Document Type:

Article

Publication Date:

4/2015

Document Language:

English

Document ID (Org No.):

62939

Frequency:

Tri-Annual

pISSN:

11100583

DOI:

10.12816/0010856