Well - Preserved Ventricular Myocyte Shortening in Goto - Kakizaki Type 2 Diabetic Rats

E. M. Gaber; P. Jayaprakash; M. A. Qureshi; M. Oz; F. C. Howarth

doi:10.7707/hmj.v7i2.311

Article Details

Well - Preserved Ventricular Myocyte Shortening in Goto - Kakizaki Type 2 Diabetic Rats

Authors:

E. M. Gaber | P. Jayaprakash | M. A. Qureshi | M. Oz | F. C. Howarth

Publisher:

Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences

Main Topics:

Medicine

Journal:

Hamdan Medical Journal 2014 vol.7 Issue 2, pp.211-217

Document Type:

Article

Publication Date:

8/2014

Document Language:

English

Document ID (Org No.):

55084

Frequency:

Tri-Annual

eISSN:

2227247X

pISSN:

22272437

DOI:

10.7707/hmj.v7i2.311

Descriptors:

Abstract:

 The global prevalence of type 2 diabetes mellitus (T2DM) is rising at aspectacular rate and the prevalence of T2DM in the United ArabEmirates is among the highest in the world. Risk factors for diabetesmellitus include obesity, sedentary lifestyle, unhealthy eating habits,family history of diabetes mellitus, genetics, increasing age, high bloodpressure and high cholesterol. A variety of diastolic and systolicdysfunctions have been reported in the hearts of type 2 diabeticpatients and the severity of abnormalities is partly dependent on thepatient’s age and the duration of diabetes mellitus. The Goto–Kakizaki(GK) rat is a genetic model of T2DM and its general characteristicsinclude fasting hyperglycaemia, impaired insulin secretion and insulinresistance. In the GK rat heart, there are a variety of dysfunctionsincluding decreased heart rate, decreased ejection fraction (mainly dueto loss of left ventricular longitudinal contraction) and prolongedshortening and/or relaxation in ventricular myocytes. Widespreadconsumption of sugar-sweetened beverages has been linked to higherincidence of obesity and T2DM. Ventricular myocyte shortening and Ca2+transport in GK type 2 diabetic rats that were fed a sucrose-enricheddiet have been investigated. GK and control rats received eitherwater or water enriched with increasing concentrations of sucrose(100–400mmol/l) for a period of 6 months. Ventricular myocyteshortening and intracellular Ca2+ were measured by video edge detectionand fluorescence photometry, respectively. Resting cell length, time topeak (TPK) shortening, time to half-relaxation of shortening andamplitude of shortening were not significantly altered in ventricularmyocytes from GK/sucrose compared with GK rats and control/sucrosecompared with control rats. TPK Ca2+ transient was prolonged inmyocytes from GK/sucrose compared with GK and control/sucrose ratsand amplitude of the Ca2+ transient was increased in myocytes fromGK/sucrose compared with control rats. Myofilament sensitivity to Ca2+was unaltered in myocytes from GK/sucrose and control/sucrosecompared with GK and control rats. In conclusion, ventricular myocyteshortening was well preserved despite some alterations in Ca2+ transportin GK rats receiving a sucrose-enriched diet.

Article Details

Well - Preserved Ventricular Myocyte Shortening in Goto - Kakizaki Type 2 Diabetic Rats

Authors:

E. M. Gaber | P. Jayaprakash | M. A. Qureshi | M. Oz | F. C. Howarth

Publisher:

Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences

Main Topics:

Medicine

Journal:

Hamdan Medical Journal 2014 vol.7 Issue 2, pp.211-217

Document Type:

Article

Publication Date:

8/2014

Document Language:

English

Document ID (Org No.):

55084

Frequency:

Tri-Annual

eISSN:

2227247X

pISSN:

22272437

DOI:

10.7707/hmj.v7i2.311

Descriptors:

DIABETES

VENTRICLE

MYOCARDIUM

WEIGHT GAIN

HYPERTENSION

INSULIN

LABORATORY ANIMALS

UNITED ARAB EMIRATES

Issues

Article Details

Authors: E. M. Gaber | P. Jayaprakash | M. A. Qureshi | M. Oz | F. C. Howarth

Publisher: Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences

Main Topics: Medicine

Journal: Hamdan Medical Journal 2014 vol.7 Issue 2, pp.211-217

Document Type: Article

Publication Date: 8/2014

Document Language: English

Document ID (Org No.): 55084

Frequency: Tri-Annual

eISSN: 2227247X

pISSN: 22272437

DOI: 10.7707/hmj.v7i2.311

Descriptors:

Issues

Authors:

E. M. Gaber | P. Jayaprakash | M. A. Qureshi | M. Oz | F. C. Howarth

Publisher:

Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences

Main Topics:

Medicine

Journal:

Hamdan Medical Journal 2014 vol.7 Issue 2, pp.211-217

Document Type:

Article

Publication Date:

8/2014

Document Language:

English

Document ID (Org No.):

55084

Frequency:

Tri-Annual

eISSN:

2227247X

pISSN:

22272437

DOI:

10.7707/hmj.v7i2.311