Effect of GNRH Analogue Treatment on Anthropometric Measurements in Girls Diagnosed with Central Precocious  Puberty: One-Year Follow-up Results

Şervan Özalkak; Melikşah Keskin; Gülin Karacan; Şenay Savaş Erdeve; Semra Çetinkaya

Article Details

Effect of GNRH Analogue Treatment on Anthropometric Measurements in Girls Diagnosed with Central Precocious Puberty: One-Year Follow-up Results

Authors:

Şervan Özalkak | Melikşah Keskin | Gülin Karacan | Şenay Savaş Erdeve | Semra Çetinkaya

Publisher:

Eskişehir Osmangazi University

Main Topics:

Çocuk Endokrinolojisi

Journal:

Osmangazi Tıp Dergisi Vol.46 Issue 4, pp.538-544

Document Type:

Article

Publication Date:

7/2024

Document Language:

Turkish

Document ID (Org No.):

2001314132

pISSN:

1305-4953

Keywords:

Abstract:

 GnRH analogsGNRHa are the gold standard treatment for central precocious pubertyCPP.There are studies reporting that body-mass-indexBMI increases, does not change and can decrease with GnRHa treatment. In this study; It was aimed to evaluate the changes in height, weight,BMI values, waist-circumference, waist-circumferenceheight ratio in girls with SPP in the first-year of GnRHa treatment. We included 63 female patients who were started on GnRHa treatment with the diagnosis of SPP in our hospital. Height, weight, BMI, waist-circumference were measured before treatmentin the first-year of treatment. Data were analyzed using SPSS25.0software. Results: The mean age was 8.410.92years. Mean height, body weight, BMI,predicted adult heightPAH,waist-circumference of the subjects increased statistically significantly in the first year compared to pre-treatment p0.001.The first-year waist-circumference percentile values of the cases were found to be higher than before the treatmentp0.002.Percentage of those with BMI percentile85 before treatment and in the first year of treatment, respectively; were 50.8,58.7p0.180.When the pre-treatment BMI was evaluated in two groups as85th percentilen31 and 85th percentilen32;There was no significant change in waist-circumferenceheight ratio, waisthip circumference ratio, BMI sds, height sds values of both groups in the first year of treatment. Height,weight,BMI,PAH,waist-circumferences, waist-circumference percentiles increased with GnRHa treatment. In subjects with BMI 85th percentile and BMI 85th percentile at baseline, no change was observed in BMI sds, height sds values, waist-circumferenceheight ratio, waisthip-circumference ratios in the first year of treatment. Further studies are needed to investigate the long-term effects of GnRHa therapy in girls with SPP,with longer duration and in larger groups.

 GnRH analogsGNRHa are the gold standard treatment for central precocious pubertyCPP.There are studies reporting that body-mass-indexBMI increases, does not change and can decrease with GnRHa treatment. In this study; It was aimed to evaluate the changes in height, weight,BMI values, waist-circumference, waist-circumferenceheight ratio in girls with SPP in the first-year of GnRHa treatment. We included 63 female patients who were started on GnRHa treatment with the diagnosis of SPP in our hospital. Height, weight, BMI, waist-circumference were measured before treatmentin the first-year of treatment. Data were analyzed using SPSS25.0software. Results: The mean age was 8.410.92years. Mean height, body weight, BMI,predicted adult heightPAH,waist-circumference of the subjects increased statistically significantly in the first year compared to pre-treatment p0.001.The first-year waist-circumference percentile values of the cases were found to be higher than before the treatmentp0.002.Percentage of those with BMI percentile85 before treatment and in the first year of treatment, respectively; were 50.8,58.7p0.180.When the pre-treatment BMI was evaluated in two groups as85th percentilen31 and 85th percentilen32;There was no significant change in waist-circumferenceheight ratio, waisthip circumference ratio, BMI sds, height sds values of both groups in the first year of treatment. Height,weight,BMI,PAH,waist-circumferences, waist-circumference percentiles increased with GnRHa treatment. In subjects with BMI 85th percentile and BMI 85th percentile at baseline, no change was observed in BMI sds, height sds values, waist-circumferenceheight ratio, waisthip-circumference ratios in the first year of treatment. Further studies are needed to investigate the long-term effects of GnRHa therapy in girls with SPP,with longer duration and in larger groups.

 GnRH analogsGNRHa are the gold standard treatment for central precocious pubertyCPP.There are studies reporting that body-mass-indexBMI increases, does not change and can decrease with GnRHa treatment. In this study; It was aimed to evaluate the changes in height, weight,BMI values, waist-circumference, waist-circumferenceheight ratio in girls with SPP in the first-year of GnRHa treatment. We included 63 female patients who were started on GnRHa treatment with the diagnosis of SPP in our hospital. Height, weight, BMI, waist-circumference were measured before treatmentin the first-year of treatment. Data were analyzed using SPSS25.0software. Results: The mean age was 8.410.92years. Mean height, body weight, BMI,predicted adult heightPAH,waist-circumference of the subjects increased statistically significantly in the first year compared to pre-treatment p0.001.The first-year waist-circumference percentile values of the cases were found to be higher than before the treatmentp0.002.Percentage of those with BMI percentile85 before treatment and in the first year of treatment, respectively; were 50.8,58.7p0.180.When the pre-treatment BMI was evaluated in two groups as85th percentilen31 and 85th percentilen32;There was no significant change in waist-circumferenceheight ratio, waisthip circumference ratio, BMI sds, height sds values of both groups in the first year of treatment. Height,weight,BMI,PAH,waist-circumferences, waist-circumference percentiles increased with GnRHa treatment. In subjects with BMI 85th percentile and BMI 85th percentile at baseline, no change was observed in BMI sds, height sds values, waist-circumferenceheight ratio, waisthip-circumference ratios in the first year of treatment. Further studies are needed to investigate the long-term effects of GnRHa therapy in girls with SPP,with longer duration and in larger groups.

 GnRH analogları GNRHa santral puberte prekokstaSPP altın standart tedavi yöntemidir. GnRHa tedavisi ile vücut kitle indeksinde VKİ artış olduğunu, değişmediğini ve azalabileceğini bildiren çalışmalar mevcuttur. Bu çalışmada; SPPli kızlarda GnRHa tedavisinin birinci yılında boy, ağırlık, VKİ değerleri ile bel çevresi, bel çevresiboy oranındaki değişimin değerlendirmesi amaçlanmıştır. Hastanemizde SPP tanısıyla GnRHa tedavisi başlanan 63 kız olgu dahil edildi. Tedavi öncesitedavinin birinci yılında boy, ağırlık, VKİ, bel çevresi ölçümleri yapıldı. Veriler SPSS 25.0 yazılımı kullanılarak analiz edildi. Yaş ortalaması 8,410,92 yıl idi. Olguların boy, vücut ağırlığı, VKİ, öngörülen son boy ÖSB, bel çevreleri ölçüm ortalamaları tedavi öncesine göre birinci yılda istatistiksel olarak çok önemli artış gösterdi p0,001. Olguların birinci yıl bel çevresi persentil değerleri tedavi öncesine göre artmış bulundu p0,002. VKİ persentili 85 olanların yüzdesi tedavi öncesi ve tedavinin birinci yılında sırasıyla; 50,8 ve 58,7 idi p0,180. Tedavi öncesi VKİ 85 persentiln31 ve 85 persentiln32 olarak iki grupta değerlendirildiğinde; tedavinin birinci yılında her iki grubun bel çevresiboy oranı, belkalça çevresi oranı, VKİ sds, boy sds değerlerinde anlamlı değişim görülmedi. GnRHa tedavisiyle boy, vücut ağırlığı, VKİ, ÖSB, bel çevreleri, bel çevresi persentilleri artmıştır. Başlangıçta VKİ85 persentil ve VKİ 85 persentil olgularda, tedavinin birinci yılında VKİ sds, boy sds değerleri ile bel çevresiboy oranı, belkalça çevresi oranları açısından değişiklik gözlenmemiştir. SPPli kızlarda GnRHa tedavisinin uzun dönem etkilerini daha uzun süreli ve daha büyük gruplarda araştıran ileri çalışmalara ihtiyaç vardır.

Article Details

Effect of GNRH Analogue Treatment on Anthropometric Measurements in Girls Diagnosed with Central Precocious Puberty: One-Year Follow-up Results

Authors:

Şervan Özalkak | Melikşah Keskin | Gülin Karacan | Şenay Savaş Erdeve | Semra Çetinkaya

Publisher:

Eskişehir Osmangazi University

Main Topics:

Çocuk Endokrinolojisi

Journal:

Osmangazi Tıp Dergisi Vol.46 Issue 4, pp.538-544

Document Type:

Article

Publication Date:

7/2024

Document Language:

Turkish

Document ID (Org No.):

2001314132

pISSN:

1305-4953

GNRH Analogue Treatment

Central Precocious Puberty

bady mass index

waist circumferenceGNRH analog tedavisi

Santral puberte prekoks

Vücut kitle indeksi

bel çevresi

Issues

Article Details

Authors: Şervan Özalkak | Melikşah Keskin | Gülin Karacan | Şenay Savaş Erdeve | Semra Çetinkaya

Publisher: Eskişehir Osmangazi University

Main Topics: Çocuk Endokrinolojisi

Journal: Osmangazi Tıp Dergisi Vol.46 Issue 4, pp.538-544

Document Type: Article

Publication Date: 7/2024

Document Language: Turkish

Document ID (Org No.): 2001314132

pISSN: 1305-4953

Issues

Authors:

Şervan Özalkak | Melikşah Keskin | Gülin Karacan | Şenay Savaş Erdeve | Semra Çetinkaya

Publisher:

Eskişehir Osmangazi University

Main Topics:

Çocuk Endokrinolojisi

Journal:

Osmangazi Tıp Dergisi Vol.46 Issue 4, pp.538-544

Document Type:

Article

Publication Date:

7/2024

Document Language:

Turkish

Document ID (Org No.):

2001314132

pISSN:

1305-4953