Methylenetetrahydrofolate Reductase (677C/T) Polymorphism in Myocardial Infarction and Hypertension

Hatem Al-Kordy Amin; Hanaa Fahmy Abdel Aziz; Ola Farouk Leheta; Hanan Kamal

doi:10.3844/ajbbsp.2012.150.156

Article Details

Methylenetetrahydrofolate Reductase (677C/T) Polymorphism in Myocardial Infarction and Hypertension

Authors:

Hatem Al-Kordy Amin | Hanaa Fahmy Abdel Aziz | Ola Farouk Leheta | Hanan Kamal

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.8 Issue 3, pp.150-156

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

2001397106

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2012.150.156

Keywords:

Abstract:

 Hyperhomocysteinemia is a well-established risk factor for cardiovascular disease and hypertension. This study aimed to assess the MTHFR gene polymorphisms (677C/T) as a potential genetic risk factor for hypertension and Myocardial Infarction (MI) in Egypt. Myocardial infarction and hypertensive diagnosed patients were divided into two groups; first comprised 50 patients aged  45 years and a third control group comprised 84. CT genotype was significantly higher in the first group (48.8%) versus control group (30%) and second group (29.4%) with (OR 2.35, 95% CI 1.3-4.2, p = 0.006). The percentage of TT genotype was 4.7, 11.8 and 15% in the three groups respectively. The percentage of MTHFR 677C→T polymorphism was significantly higher in patients with hypertension than normotensive. MTHFR 677C→T polymorphism in Egyptian MI and hypertensive patients has no direct role in developing such diseases but in combination with high levels of cholesterol, LDL-C and triglycerides might constitute a probable potentiating factor for MI and hypertension among Egyptian patients and could not be used as a predictor for early diagnosis without considering other factors.

Article Details

Methylenetetrahydrofolate Reductase (677C/T) Polymorphism in Myocardial Infarction and Hypertension

Authors:

Hatem Al-Kordy Amin | Hanaa Fahmy Abdel Aziz | Ola Farouk Leheta | Hanan Kamal

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.8 Issue 3, pp.150-156

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

2001397106

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2012.150.156

MTHFR 677C&rarr

T Gene Polymorphism

Hyperhomocysteinemia

Hypertension

Myocardial Infarction

Egyptian Patients

Issues

Article Details

Methylenetetrahydrofolate Reductase (677C/T) Polymorphism in Myocardial Infarction and Hypertension

Authors: Hatem Al-Kordy Amin | Hanaa Fahmy Abdel Aziz | Ola Farouk Leheta | Hanan Kamal

Publisher: Science Publications

Journal: American Journal of Biochemistry and Biotechnology Vol.8 Issue 3, pp.150-156

Document Type: Article

Publication Date: 9/2012

Document Language: English

Document ID (Org No.): 2001397106

pISSN: 1558-6332

DOI: 10.3844/ajbbsp.2012.150.156

MTHFR 677C&rarr

T Gene Polymorphism

Hyperhomocysteinemia

Hypertension

Myocardial Infarction

Egyptian Patients

Issues

Authors:

Hatem Al-Kordy Amin | Hanaa Fahmy Abdel Aziz | Ola Farouk Leheta | Hanan Kamal

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.8 Issue 3, pp.150-156

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

2001397106

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2012.150.156