Effects of the Systemic Administration of Omega -3 Polyunsaturated Fatty Acid on Experimental Periodontitis

Aveen Ageel Jalal; Zewar A. AL-Qassab; Rafel A. AL-Rawi

doi:10.22317/jcms.v5i4.661

Article Details

Effects of the Systemic Administration of Omega -3 Polyunsaturated Fatty Acid on Experimental Periodontitis

Authors:

Aveen Ageel Jalal | Zewar A. AL-Qassab | Rafel A. AL-Rawi

Publisher:

Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal:

Journal of Contemporary Medical Sciences Vol.5 Issue 4, pp.227-233

Document Type:

Article

Publication Date:

8/2019

Document Language:

English

Document ID (Org No.):

2001379316

pISSN:

2413-0516

DOI:

10.22317/jcms.v5i4.661

Keywords:

Abstract:

 Objective: The present study was aimed to investigate and evaluate the effects of eicosapentaenoic acid (EPA) on ligature induced periodontitis in rats through the biochemical analysis for ratâ€™s serum level of CRP, ALP and MDA.
 
Methods: Periodontitis was induced for the studied animals by ligation around the upper central incisor. Twenty five animals were used as a control and gavaged by water only, and one hundred animals with the induced periodontitis were divided into four equal groups according to the treatment used which was started at time of ligation removal: Water (P/W), scaling/root planing (P/SRP), 60mg/kg EPA(P/EPA), and scaling/root planing together with EPA(P/SRP+EPA). Blood was taken by cardiac puncture, after three hours, 24 hours, three days, one week and two weeks for biochemical analysis.
Results: The P/SRP+EPA treatment group showed significant decrease (p<0.05) in serum CRP, significant increase in serum ALP, significant decrease in serum MDA after one week, three days, and three hours  respectively in comparison with the P/W treatment group.
Conclusion: The treatment by SRP with 60mg/kg EPA is better than each one alone and can be used for treatment of periodontitis.

Article Details

Effects of the Systemic Administration of Omega -3 Polyunsaturated Fatty Acid on Experimental Periodontitis

Authors:

Aveen Ageel Jalal | Zewar A. AL-Qassab | Rafel A. AL-Rawi

Publisher:

Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal:

Journal of Contemporary Medical Sciences Vol.5 Issue 4, pp.227-233

Document Type:

Article

Publication Date:

8/2019

Document Language:

English

Document ID (Org No.):

2001379316

pISSN:

2413-0516

DOI:

10.22317/jcms.v5i4.661

Periodontitis

Eicosapentaenoic acid

Alveolar bone resorption

Omega-3

Issues

Article Details

Effects of the Systemic Administration of Omega -3 Polyunsaturated Fatty Acid on Experimental Periodontitis

Authors: Aveen Ageel Jalal | Zewar A. AL-Qassab | Rafel A. AL-Rawi

Publisher: Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal: Journal of Contemporary Medical Sciences Vol.5 Issue 4, pp.227-233

Document Type: Article

Publication Date: 8/2019

Document Language: English

Document ID (Org No.): 2001379316

pISSN: 2413-0516

DOI: 10.22317/jcms.v5i4.661

Periodontitis

Eicosapentaenoic acid

Alveolar bone resorption

Omega-3

Issues

Authors:

Aveen Ageel Jalal | Zewar A. AL-Qassab | Rafel A. AL-Rawi

Publisher:

Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal:

Journal of Contemporary Medical Sciences Vol.5 Issue 4, pp.227-233

Document Type:

Article

Publication Date:

8/2019

Document Language:

English

Document ID (Org No.):

2001379316

pISSN:

2413-0516

DOI:

10.22317/jcms.v5i4.661