Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery

Ali Asram Sağıroğlu; Beyza Sümeyye Aydın

Article Details

Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery

Authors:

Ali Asram Sağıroğlu | Beyza Sümeyye Aydın

Publisher:

Marmara University

Main Topics:

Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Journal:

Journal of Research in Pharmacy Vol.28 Issue 2, pp.470-481

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346201

pISSN:

2630-6344

Keywords:

Abstract:

 This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.73.6, accompanied by a narrow particle size distribution 179.9  5.4 nm. In vitro release studies unveiled cumulative release percentages of 71.986.52 for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.

 This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.73.6, accompanied by a narrow particle size distribution 179.9  5.4 nm. In vitro release studies unveiled cumulative release percentages of 71.986.52 for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.

 This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.73.6, accompanied by a narrow particle size distribution 179.9  5.4 nm. In vitro release studies unveiled cumulative release percentages of 71.986.52 for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.

 This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.73.6, accompanied by a narrow particle size distribution 179.9  5.4 nm. In vitro release studies unveiled cumulative release percentages of 71.986.52 for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.

Article Details

Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery

Authors:

Ali Asram Sağıroğlu | Beyza Sümeyye Aydın

Publisher:

Marmara University

Main Topics:

Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Journal:

Journal of Research in Pharmacy Vol.28 Issue 2, pp.470-481

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346201

pISSN:

2630-6344

Transfersomes

Bakuchiol

Hyperpigmentation

Skin permeation

Topical delivery

Issues

Article Details

Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery

Authors: Ali Asram Sağıroğlu | Beyza Sümeyye Aydın

Publisher: Marmara University

Main Topics: Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Journal: Journal of Research in Pharmacy Vol.28 Issue 2, pp.470-481

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001346201

pISSN: 2630-6344

Transfersomes

Bakuchiol

Hyperpigmentation

Skin permeation

Topical delivery

Issues

Authors:

Ali Asram Sağıroğlu | Beyza Sümeyye Aydın

Publisher:

Marmara University

Main Topics:

Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Journal:

Journal of Research in Pharmacy Vol.28 Issue 2, pp.470-481

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346201

pISSN:

2630-6344