Formulation & Evaluation of ointment containing anthocyanin of Garcinia indica: A single arm open label study

N.A.

Article Details

Formulation & Evaluation of ointment containing anthocyanin of Garcinia indica: A single arm open label study

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1547-1559

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347868

pISSN:

2630-6344

Keywords:

Abstract:

 The study was aimed to formulate and evaluate ointment containing anthocyanin extract to study of anti-fungal activity. Anthocyanin was extracted from the Garcinia indica.by maceration technique using 0.1 HClvv inwater asa solvent. Anthocyanin ointment were formulated using various excipients and different concentration of anthocyanin. Formulated ointment was evaluated for pH, spreadability, viscosity, extrudability, drug content, in-vitro anthocyanin release, and best formulation were evaluated for Clinical study. The pH of formulations was fairly constantabout6.6-6.8 with in the range of skin pH. Formulation F4 showed less viscous and showed good spreadability and F5 showed excellent extrudability compared to other ointment formulations. The formulations F5 showed better percentage anthocyanin content of 97.960.70 respectively. All formulations were evaluated for cumulative percentage anthocyanin release, were F5 formulation showed92 at the end of 6 hour. Anthocyanin extract and formulation F5 showed anti-fungal activity against fungi pathogen such as Candida albicans and Candida krusei. Formulation F5 showed positive results against In-vivo superficial dermatophytic infections and effect showed significant on all parameters.

 The study was aimed to formulate and evaluate ointment containing anthocyanin extract to study of anti-fungal activity. Anthocyanin was extracted from the Garcinia indica.by maceration technique using 0.1 HClvv inwater asa solvent. Anthocyanin ointment were formulated using various excipients and different concentration of anthocyanin. Formulated ointment was evaluated for pH, spreadability, viscosity, extrudability, drug content, in-vitro anthocyanin release, and best formulation were evaluated for Clinical study. The pH of formulations was fairly constantabout6.6-6.8 with in the range of skin pH. Formulation F4 showed less viscous and showed good spreadability and F5 showed excellent extrudability compared to other ointment formulations. The formulations F5 showed better percentage anthocyanin content of 97.960.70 respectively. All formulations were evaluated for cumulative percentage anthocyanin release, were F5 formulation showed92 at the end of 6 hour. Anthocyanin extract and formulation F5 showed anti-fungal activity against fungi pathogen such as Candida albicans and Candida krusei. Formulation F5 showed positive results against In-vivo superficial dermatophytic infections and effect showed significant on all parameters.

 The study was aimed to formulate and evaluate ointment containing anthocyanin extract to study of anti-fungal activity. Anthocyanin was extracted from the Garcinia indica.by maceration technique using 0.1 HClvv inwater asa solvent. Anthocyanin ointment were formulated using various excipients and different concentration of anthocyanin. Formulated ointment was evaluated for pH, spreadability, viscosity, extrudability, drug content, in-vitro anthocyanin release, and best formulation were evaluated for Clinical study. The pH of formulations was fairly constantabout6.6-6.8 with in the range of skin pH. Formulation F4 showed less viscous and showed good spreadability and F5 showed excellent extrudability compared to other ointment formulations. The formulations F5 showed better percentage anthocyanin content of 97.960.70 respectively. All formulations were evaluated for cumulative percentage anthocyanin release, were F5 formulation showed92 at the end of 6 hour. Anthocyanin extract and formulation F5 showed anti-fungal activity against fungi pathogen such as Candida albicans and Candida krusei. Formulation F5 showed positive results against In-vivo superficial dermatophytic infections and effect showed significant on all parameters.

 The study was aimed to formulate and evaluate ointment containing anthocyanin extract to study of anti-fungal activity. Anthocyanin was extracted from the Garcinia indica.by maceration technique using 0.1 HClvv inwater asa solvent. Anthocyanin ointment were formulated using various excipients and different concentration of anthocyanin. Formulated ointment was evaluated for pH, spreadability, viscosity, extrudability, drug content, in-vitro anthocyanin release, and best formulation were evaluated for Clinical study. The pH of formulations was fairly constantabout6.6-6.8 with in the range of skin pH. Formulation F4 showed less viscous and showed good spreadability and F5 showed excellent extrudability compared to other ointment formulations. The formulations F5 showed better percentage anthocyanin content of 97.960.70 respectively. All formulations were evaluated for cumulative percentage anthocyanin release, were F5 formulation showed92 at the end of 6 hour. Anthocyanin extract and formulation F5 showed anti-fungal activity against fungi pathogen such as Candida albicans and Candida krusei. Formulation F5 showed positive results against In-vivo superficial dermatophytic infections and effect showed significant on all parameters.

Article Details

Formulation & Evaluation of ointment containing anthocyanin of Garcinia indica: A single arm open label study

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1547-1559

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347868

pISSN:

2630-6344

Anthocyanin

Garcinia indica

Anti-fungal

Superficial dermatophytic infection study

Topical ointment

Issues

Article Details

Formulation & Evaluation of ointment containing anthocyanin of Garcinia indica: A single arm open label study

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.27 Issue 4, pp.1547-1559

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001347868

pISSN: 2630-6344

Anthocyanin

Garcinia indica

Anti-fungal

Superficial dermatophytic infection study

Topical ointment

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1547-1559

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347868

pISSN:

2630-6344