Antidiabetic and Antihyperlipidemic Effect of Balanites Aegyptiaca Seeds ( Aqueous Extract ) on Diabetic Rats

Eman G. E. Helal; Samia M. Abd El-Wahab; Hesham El Refaey

doi:10.12816/0000610

Article Details

Antidiabetic and Antihyperlipidemic Effect of Balanites Aegyptiaca Seeds ( Aqueous Extract ) on Diabetic Rats

Authors:

Eman G. E. Helal | Samia M. Abd El-Wahab | Hesham El Refaey

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2013 vol.52, pp.725-739

Document Type:

Article

Publication Date:

7/2013

Document Language:

English

Document ID (Org No.):

32758

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0000610

Descriptors:

Keywords:

Abstract:

 Objectives: Type II diabetes mellitus is increasing health problems that negatively affect health care systems worldwide. There is a constant urge to develop new therapies with better effects, lower side effects at lower prices to treat this disease. Therefore, the present study carried out to investigate whether Balanites aegyptiaca (seeds) could treat the hyperglycemic, dislipidemic, liver, and kidney toxicity and the pancreatic damage in diabetic rats.
Material and method: fifteen adult male albino rats were divided into two groups; group 1: control group, group 2: alloxan induced diabetic rats that divided into two subgroups; subgroup1: diabetic untreated rats, subgroup2: diabetic treated with aqueous extract of B. aegyptiaca (seeds). After thirty days of treatment, all rats were sacrificed. Blood sample were collected to estimate some hematological and biochemical parameters. Liver samples were collected to determine their glycogen content and pancreatic samples were obtained and processed for microscopic and quantitative evaluation of α, β & δ-cells number.
Results: diabetic group recorded reduction in body weight's gained, hyperglycemia, hypoinsulinemia, significant increase in some parameters of liver and kidney functions, dislipidemia, changes in proteins level and decreased liver glycogen content. While, treatment with B. aegyptiaca (seeds) was ameliorated most of the toxic effects of alloxan and showed partially improvement in histological changes produced by alloxan.
Conclusion: The aqueous extract of B. aegyptiaca (seeds) has hypoglycemic, hypolipidemic effects, increasing insulin level, and decreasing insulin resistance. Moreover, ameliorate the most complication associated with diabetes mellitus

Article Details

Antidiabetic and Antihyperlipidemic Effect of Balanites Aegyptiaca Seeds ( Aqueous Extract ) on Diabetic Rats

Authors:

Eman G. E. Helal | Samia M. Abd El-Wahab | Hesham El Refaey

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2013 vol.52, pp.725-739

Document Type:

Article

Publication Date:

7/2013

Document Language:

English

Document ID (Org No.):

32758

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0000610

Descriptors:

DIABETES

HYPERGLYCAEMIA

PLANT EXTRACTS

SEEDS

INSULIN

THERAPY

LABORATORY ANIMALS

Alloxan

Hypoglycemia

Diabetic

Balanites aegyptiaca

Issues

Article Details

Authors: Eman G. E. Helal | Samia M. Abd El-Wahab | Hesham El Refaey

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2013 vol.52, pp.725-739

Document Type: Article

Publication Date: 7/2013

Document Language: English

Document ID (Org No.): 32758

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

DOI: 10.12816/0000610

Descriptors:

Issues

Authors:

Eman G. E. Helal | Samia M. Abd El-Wahab | Hesham El Refaey

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2013 vol.52, pp.725-739

Document Type:

Article

Publication Date:

7/2013

Document Language:

English

Document ID (Org No.):

32758

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0000610