Synthesis and Antibacterial Activity of Some Novel Schiff S-Bases Compounds Containing Oxadiazole Ring

J. H. Tomma; A. H. Raheema; I. H. Rouil

Article Details

Synthesis and Antibacterial Activity of Some Novel Schiff S-Bases Compounds Containing Oxadiazole Ring

Authors:

J. H. Tomma | A. H. Raheema | I. H. Rouil

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.18 Issue 1, pp.41-49

Document Type:

Article

Publication Date:

1/2005

Document Language:

English

Document ID (Org No.):

2001376374

pISSN:

2521-3407

Abstract:

 Condensation of 4-methoxybenzoyl hydrazine with 4- aminobenzoic acid in the presence of POCl3 gave the oxadiazole derivative [III] .This compound was demethylated with aluminium chloride to give series of 2- (4-hydroxy phenyl)-5-(4-amino phenyl) 1,3,4-oxadiazole [IV]. Series of Schiff s bases [V]n were synthesized by the condensation of compound [IV] with 4-n-alkoxy benzaldehyde in the presence of glacial acetic acid. Condensation of compounds [VI]n.  with adipoyl chloride in dry pyridine leads to the formation of a new homologous series [VI]n. The structures of the synthesized compounds were confirmed by physical and spectral means The new compounds [VI]n have been screened for their antibacterial activities . The results showed considerable antibacterial activity against Escherichia Coli (G-),but did not show any antibacterial activity against Staphylococcus aureus (G+).

Article Details

Synthesis and Antibacterial Activity of Some Novel Schiff S-Bases Compounds Containing Oxadiazole Ring

Authors: J. H. Tomma | A. H. Raheema | I. H. Rouil

Publisher: University of Baghdad

Journal: Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.18 Issue 1, pp.41-49

Document Type: Article

Publication Date: 1/2005

Document Language: English

Document ID (Org No.): 2001376374

pISSN: 2521-3407

Issues

Authors:

J. H. Tomma | A. H. Raheema | I. H. Rouil

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.18 Issue 1, pp.41-49

Document Type:

Article

Publication Date:

1/2005

Document Language:

English

Document ID (Org No.):

2001376374

pISSN:

2521-3407