Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

Nadir Bilgin Akgül; Muhammed Mehdi Üremiş; Nuray Üremiş; Ebru Annaç; Rıfat Cesur Bozat; Murat Koca; Ahmet Özkaya; Elif Merve Betül Yanılmaz

Article Details

Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

Authors:

Nadir Bilgin Akgül | Muhammed Mehdi Üremiş | Nuray Üremiş | Ebru Annaç | Rıfat Cesur Bozat | Murat Koca | Ahmet Özkaya | Elif Merve Betül Yanılmaz

Publisher:

Adıyaman University

Main Topics:

Sentetik Biyoloji

Journal:

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.10 Issue 1, pp.1-9

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001315234

pISSN:

2458-9179

Keywords:

Abstract:

 Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate CM against the renal toxicity of Bisphenol A BPA. Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPACM. Total Antioxidant Status TAS, Total Oxidant Status TOS, and Malondialdehyde MDA levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters. Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM. Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.

 Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate CM against the renal toxicity of Bisphenol A BPA. Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPACM. Total Antioxidant Status TAS, Total Oxidant Status TOS, and Malondialdehyde MDA levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters. Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM. Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.

 Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate CM against the renal toxicity of Bisphenol A BPA. Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPACM. Total Antioxidant Status TAS, Total Oxidant Status TOS, and Malondialdehyde MDA levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters. Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM. Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.

 Amaç: Bu çalışmada sentezlenen kumarin etil 7-hidroksi-2-imino-2H-kromen-3 karboksilatın CM Bisfenol Anın BPA renal toksisitesine karşı koruyucu etkinliğinin araştırılması amaçlandı. Gereç ve Yöntem: CM molekülü, 2,4-dihidroksibenzaldehit ve etil siyanoasetat arasındaki reaksiyon yoluyla sentezlendi. Hayvan denemeleri için ratlar dört gruba ayrıldı: kontrol, BPA, CM ve BPA  CM. Böbrek dokusunda Toplam Antioksidan Durum TAS, Toplam Oksidan Durum TOS ve Malondialdehit MDA seviyeleri değerlendirildi. Serum örnekleri Total-Native tiyol ve böbrek fonksiyon testi parametreleri açısından analiz edildi. Bulgular: BPA ile tedavi edilen grupta TAS ve tiyol düzeylerinde önemli düşüşler, TOS ve MDA düzeylerinde ise artışlar görüldü. Ancak CM ile bu yan etkiler önemli ölçüde azaldı. Sonuç: Bu çalışmada elde edilen sonuçlar CM molekülünün BPA kaynaklı böbrek toksisitesine karşı koruyucu etkiye sahip olduğunu göstermektedir.

Article Details

Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

Authors:

Nadir Bilgin Akgül | Muhammed Mehdi Üremiş | Nuray Üremiş | Ebru Annaç | Rıfat Cesur Bozat | Murat Koca | Ahmet Özkaya | Elif Merve Betül Yanılmaz

Publisher:

Adıyaman University

Main Topics:

Sentetik Biyoloji

Journal:

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.10 Issue 1, pp.1-9

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001315234

pISSN:

2458-9179

Bisphenol A

Coumarin

Kidney

Antioxidant

Oxidative stresBisfenol A

Kumarin

Böbrek

Antioksidan

Oksidatif stres

Issues

Article Details

Authors: Nadir Bilgin Akgül | Muhammed Mehdi Üremiş | Nuray Üremiş | Ebru Annaç | Rıfat Cesur Bozat | Murat Koca | Ahmet Özkaya | Elif Merve Betül Yanılmaz

Publisher: Adıyaman University

Main Topics: Sentetik Biyoloji

Journal: Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.10 Issue 1, pp.1-9

Document Type: Article

Publication Date: 4/2024

Document Language: English

Document ID (Org No.): 2001315234

pISSN: 2458-9179

Issues

Authors:

Nadir Bilgin Akgül | Muhammed Mehdi Üremiş | Nuray Üremiş | Ebru Annaç | Rıfat Cesur Bozat | Murat Koca | Ahmet Özkaya | Elif Merve Betül Yanılmaz

Publisher:

Adıyaman University

Main Topics:

Sentetik Biyoloji

Journal:

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.10 Issue 1, pp.1-9

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001315234

pISSN:

2458-9179