In Vitro Cytotoxic Effects of Some Fumaria L. (Papaveraceae) Species Methanolic Extracts on Cancer Cell Lines

Pelin Yılmaz Sancar; Irmak Icen Taskın

Article Details

In Vitro Cytotoxic Effects of Some Fumaria L. (Papaveraceae) Species Methanolic Extracts on Cancer Cell Lines

Authors:

Pelin Yılmaz Sancar | Irmak Icen Taskın

Publisher:

Bingol University

Journal:

Türk Doğa ve Fen Dergisi Vol.13 Issue 2, pp.25-29

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001321140

pISSN:

2149-6366

Keywords:

Abstract:

 The Fumaria L. species Papaveraceae, is known colloquially as Şahtere. This species, which has been proven to contain significantly rich components, is used by people to treat a number of different diseases. This study investigated the cytotoxic effects of the methanolic extracts of above-ground portions of Fumaria asepala Boiss. and Fumaria schleicheri Soy.-Will. subsp. microcarpa Boiss. ex Hausskn. taxons against Beas-2B, sh-sy5, HCT116 and A549 cell lines. The changes in cancer cell vitality were identified using the 3-4.5-dimethylthiazol -2-il-2.5-diphenyltetrazolium bromide MTT. While the results showed that F. asepala and F. schleicheri subsp. microcarpas methanolic extracts presented a meaningful decrease in the vitality of colon HCT-116 cancer cells, no cytotoxic effect was achieved on lung A549 cancer and brain sh-sy5 cancer cells. Also, the herbal extracts did not create any toxic effect on healthy lung cells Beas-2B.

 The Fumaria L. species Papaveraceae, is known colloquially as Şahtere. This species, which has been proven to contain significantly rich components, is used by people to treat a number of different diseases. This study investigated the cytotoxic effects of the methanolic extracts of above-ground portions of Fumaria asepala Boiss. and Fumaria schleicheri Soy.-Will. subsp. microcarpa Boiss. ex Hausskn. taxons against Beas-2B, sh-sy5, HCT116 and A549 cell lines. The changes in cancer cell vitality were identified using the 3-4.5-dimethylthiazol -2-il-2.5-diphenyltetrazolium bromide MTT. While the results showed that F. asepala and F. schleicheri subsp. microcarpas methanolic extracts presented a meaningful decrease in the vitality of colon HCT-116 cancer cells, no cytotoxic effect was achieved on lung A549 cancer and brain sh-sy5 cancer cells. Also, the herbal extracts did not create any toxic effect on healthy lung cells Beas-2B.

 The Fumaria L. species Papaveraceae, is known colloquially as Şahtere. This species, which has been proven to contain significantly rich components, is used by people to treat a number of different diseases. This study investigated the cytotoxic effects of the methanolic extracts of above-ground portions of Fumaria asepala Boiss. and Fumaria schleicheri Soy.-Will. subsp. microcarpa Boiss. ex Hausskn. taxons against Beas-2B, sh-sy5, HCT116 and A549 cell lines. The changes in cancer cell vitality were identified using the 3-4.5-dimethylthiazol -2-il-2.5-diphenyltetrazolium bromide MTT. While the results showed that F. asepala and F. schleicheri subsp. microcarpas methanolic extracts presented a meaningful decrease in the vitality of colon HCT-116 cancer cells, no cytotoxic effect was achieved on lung A549 cancer and brain sh-sy5 cancer cells. Also, the herbal extracts did not create any toxic effect on healthy lung cells Beas-2B.

 Fumaria cinsi Papaveraceae halk arasında Şahtere olarak bilinir. Son derece zengin bileşiklere sahip olduğu kanıtlanmış olan cins, halk arasında birçok rahatsızlığın tedavisinde kullanılmaktadır. Bu çalışmada, Fumaria asepala Boiss. ve Fumaria schleicheri Soy.-Will. subsp. microcarpa Boiss. ex Hausskn. taksonlarının toprak üstü kısımlarının metanolik ekstraktının Beas-2B, sh-sy5, HCT116 ve A549 hücre hatlarına karşı sitotoksik özellikleri araştırıldı. Kanser hücrelerinin canlılığındaki değişiklikler 3-4,5-dimetiltiazol-2-il-2,5-difeniltetrazolyum bromür MTT yöntemi kullanılarak tespit edildi. Sonuçlar, F. asepala ve F. schichleiri subsp. microcarpanın metanolik ekstraktının özellikle kolon HCT-116 kanseri hücrelerinin hücre canlılığında istatistiksel olarak anlamlı bir azalma olduğunu gösterirken, akciğer A549 kanseri ve beyin sh-sy5 kanseri hücreleri üzerinde sitotoksik etkinlik sağlamamıştır. Ayrıca bitkisel ekstraktlar, sağlıklı akciğer hücreleri Beas-2B üzerinde ise herhangi bir toksik etki yaratmamıştır.

Article Details

In Vitro Cytotoxic Effects of Some Fumaria L. (Papaveraceae) Species Methanolic Extracts on Cancer Cell Lines

Authors:

Pelin Yılmaz Sancar | Irmak Icen Taskın

Publisher:

Bingol University

Journal:

Türk Doğa ve Fen Dergisi Vol.13 Issue 2, pp.25-29

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001321140

pISSN:

2149-6366

Fumaria

Cytotoxic

Beas-2B

sh-sy5

HCT116

A549Fumaria

Sitotoksik

Beas-2B

sh-sy5

HCT116

A549

Issues

Article Details

Authors: Pelin Yılmaz Sancar | Irmak Icen Taskın

Publisher: Bingol University

Journal: Türk Doğa ve Fen Dergisi Vol.13 Issue 2, pp.25-29

Document Type: Article

Publication Date: 6/2024

Document Language: English

Document ID (Org No.): 2001321140

pISSN: 2149-6366

Issues

Authors:

Pelin Yılmaz Sancar | Irmak Icen Taskın

Publisher:

Bingol University

Journal:

Türk Doğa ve Fen Dergisi Vol.13 Issue 2, pp.25-29

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001321140

pISSN:

2149-6366