Effect of Different Dosages of Intravaginal Misoprostol for Second Trimester Pregnancy Termination

Maysoon Sharief; Enaas S. Al-Khayat

doi:10.12816/0008184

Article Details

Effect of Different Dosages of Intravaginal Misoprostol for Second Trimester Pregnancy Termination

Authors:

Maysoon Sharief | Enaas S. Al-Khayat

Publisher:

Islamic World Academy of Sciences

Main Topics:

Medicine

Journal:

Medical Journal of Islamic World Academy of Sciences 2014 Vol.22 Issue 3, pp.133-138

Document Type:

Article

Publication Date:

7/2014

Document Language:

English

Document ID (Org No.):

56191

Frequency:

Quarterly

pISSN:

10163360

DOI:

10.12816/0008184

Descriptors:

Keywords:

Abstract:

 Miscarriage is a common complication of early pregnancy; however; curettage and dilation are considered standardmethods taking care of early pregnancy failure. Misoprostol has been used as an alternative agent for termination ofearly pregnancy. Therefore, this study was aimed to compare the efficacy and side effects of two different intravaginalmisoprostol trials for the second trimester pregnancy termination of missed miscarriage between 14 and 23 weeks.
A clinical trial was carried out in Basrah Maternity & Children Hospital during the period from October 2011 to November2012. A total of 100 women experienced missed miscarriages at 14-23 weeks of gestation were admitted for medicaltermination of pregnancy. Patients were divided into the following two groups:Group 1: 50 patients received 400 μg of intravaginal misoprostol/8 hours. Group 2: 50 patients received 800 μgof intravaginal misoprostol/8 hours. The patients were followed up for 24 hours. The primary outcome measure wasinduction-miscarriage interval; the secondary outcomes were the rate of successful miscarriage and complete miscarriage;the incidence of side effects was compared in both groups.The rates of successful termination of pregnancy in both groups 1 and 2 were 86% and 90%, respectively. The successrates of the drug in group 1 were 0%, 12%, 36%, 34%, 10%, and 4% after first, second, third, fourth, fifth, and sixth doses,respectively; whereas, the success rates in group 2 were 24%, 34%, 24%, 12%, 4%, and 0% after first, second, third,fourth, fifth, and sixth doses, respectively. The mean numbers of doses required to achieve response were 3.66 and 2.44in groups 1 and 2, respectively. The mean induction to miscarriage interval was significantly shorter for group 2 than forgroup 1 (15.46 ±9.21 hours and 22.96 ±9.44 hours, respectively) (P<0.00001). Drug dosages showed more side effectsin group 2 patients than in group 1 patients with no significant differences. Miscarriages were reported more in group 2patients (82%) than in group 1 patients (48%) (P<0.001) within 24 hours.Both trials were effective for terminating the second trimester pregnancy of missed miscarriage. However, 800 mgintravaginal mistoprostol trial resulted in shorter induction-miscarriage

Article Details

Effect of Different Dosages of Intravaginal Misoprostol for Second Trimester Pregnancy Termination

Authors:

Maysoon Sharief | Enaas S. Al-Khayat

Publisher:

Islamic World Academy of Sciences

Main Topics:

Medicine

Journal:

Medical Journal of Islamic World Academy of Sciences 2014 Vol.22 Issue 3, pp.133-138

Document Type:

Article

Publication Date:

7/2014

Document Language:

English

Document ID (Org No.):

56191

Frequency:

Quarterly

pISSN:

10163360

DOI:

10.12816/0008184

Descriptors:

GYNECOLOGY

PREGNANCY DISORDERS

ABORTION TECHNIQUES

DRUGS

SIDE EFFECTS

PATIENTS

Gynecology

Miscarriage

Misoprostol

Route of Administration

Issues

Article Details

Authors: Maysoon Sharief | Enaas S. Al-Khayat

Publisher: Islamic World Academy of Sciences

Main Topics: Medicine

Journal: Medical Journal of Islamic World Academy of Sciences 2014 Vol.22 Issue 3, pp.133-138

Document Type: Article

Publication Date: 7/2014

Document Language: English

Document ID (Org No.): 56191

Frequency: Quarterly

pISSN: 10163360

DOI: 10.12816/0008184

Descriptors:

Issues

Authors:

Maysoon Sharief | Enaas S. Al-Khayat

Publisher:

Islamic World Academy of Sciences

Main Topics:

Medicine

Journal:

Medical Journal of Islamic World Academy of Sciences 2014 Vol.22 Issue 3, pp.133-138

Document Type:

Article

Publication Date:

7/2014

Document Language:

English

Document ID (Org No.):

56191

Frequency:

Quarterly

pISSN:

10163360

DOI:

10.12816/0008184