The effect of astaxanthin on amiodarone induced cardiac tissue damage in rat

Özlem Kara; Asuman Kilitci

Article Details

The effect of astaxanthin on amiodarone induced cardiac tissue damage in rat

Authors:

Özlem Kara | Asuman Kilitci

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.194-199

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282245

pISSN:

2602-3032

Keywords:

Abstract:

 Purpose: The aim of this study was to evaluate the effect of astaxanthin on amiodarone induced cardiac tissue damage. Materials and Methods: 3 groups were formed using 30 Wistar albino rats. In group 1 control group n10, neither any drugs were given nor anything was performed. In group 2 amiodarone group n10, 100 mgkg amiodarone was given for 7 days. In group 3 amiodaroneastaxanthin group n10, 100 mgkg amiodarone and 25 mgkg astaxanthin were given for 7 days. Hearts were surgically extirpated in all groups. Blood malondialdehyde MDA levels and activities of catalase CAT and superoxide dismutase SOD were measured. Also, toxicity markers such as edema, hemorrhage, fibrosis, inflammatory cell infiltration were assessed by examining the slides prepared from cardiac tissue with microscopy. Results: The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than group 3. Tissue damage was significantly higher in group 2 than group 3. Conclusion: According to our short term findings, astaxanthin reversed the toxicity of amiodarone on cardiac tissue. In the light of these promising results, we suggest that astaxanthin usage should be thought to protect the cardiac damage due to amiodarone.

 Purpose: The aim of this study was to evaluate the effect of astaxanthin on amiodarone induced cardiac tissue damage. Materials and Methods: 3 groups were formed using 30 Wistar albino rats. In group 1 control group n10, neither any drugs were given nor anything was performed. In group 2 amiodarone group n10, 100 mgkg amiodarone was given for 7 days. In group 3 amiodaroneastaxanthin group n10, 100 mgkg amiodarone and 25 mgkg astaxanthin were given for 7 days. Hearts were surgically extirpated in all groups. Blood malondialdehyde MDA levels and activities of catalase CAT and superoxide dismutase SOD were measured. Also, toxicity markers such as edema, hemorrhage, fibrosis, inflammatory cell infiltration were assessed by examining the slides prepared from cardiac tissue with microscopy. Results: The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than group 3. Tissue damage was significantly higher in group 2 than group 3. Conclusion: According to our short term findings, astaxanthin reversed the toxicity of amiodarone on cardiac tissue. In the light of these promising results, we suggest that astaxanthin usage should be thought to protect the cardiac damage due to amiodarone.

 Purpose: The aim of this study was to evaluate the effect of astaxanthin on amiodarone induced cardiac tissue damage. Materials and Methods: 3 groups were formed using 30 Wistar albino rats. In group 1 control group n10, neither any drugs were given nor anything was performed. In group 2 amiodarone group n10, 100 mgkg amiodarone was given for 7 days. In group 3 amiodaroneastaxanthin group n10, 100 mgkg amiodarone and 25 mgkg astaxanthin were given for 7 days. Hearts were surgically extirpated in all groups. Blood malondialdehyde MDA levels and activities of catalase CAT and superoxide dismutase SOD were measured. Also, toxicity markers such as edema, hemorrhage, fibrosis, inflammatory cell infiltration were assessed by examining the slides prepared from cardiac tissue with microscopy. Results: The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than group 3. Tissue damage was significantly higher in group 2 than group 3. Conclusion: According to our short term findings, astaxanthin reversed the toxicity of amiodarone on cardiac tissue. In the light of these promising results, we suggest that astaxanthin usage should be thought to protect the cardiac damage due to amiodarone.

 Amaç: BU çalışmada astaksantinin amiodaron kaynaklı kalp dokusu hasarı üzerindeki etkisinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: 30 adet Wistar albino rat kullanılarak 3 grup oluşturuldu. Grup 1de kontrol grubu n10 herhangi bir ilaç verilmedi ve herhangi bir işlem yapılmadı. Grup 2de amiodaron grubu n10 7 gün boyunca 100 mgkg amiodaron verildi. Grup 3te amiodaronastaksantin grubu n10 7 gün boyunca 100 mgkg amiodaron ve 25 mgkg astaksantin verildi. Kalp tüm gruplarda cerrahi olarak ekstirpe edildi. Kan malondialdehid MDA seviyeleri ve katalaz CAT ve süperoksit dismutaz SOD aktiviteleri ölçüldü. Ayrıca kalp dokusundan hazırlanan preparatlar mikroskopla incelenerek ödem, hemoraji, fibrozis, inflamatuvar hücre infiltrasyonu gibi toksisite belirteçleri değerlendirildi. Bulgular: Grup 2de grup 3e göre MDA düzeyleri anlamlı olarak yüksek, SOD ve CAT aktiviteleri daha düşüktü. Doku hasarı grup 2de grup 3e göre anlamlı olarak daha yüksekti. Sonuç: Kısa dönem bulgularımıza göre astaksantin, amiodaronun kalp dokusu üzerindeki toksisitesini tersine çevirdi. Bu ümit verici sonuçların ışığında, biz amiodarona bağlı kardiyak hasardan korunmak için astaksantin kullanılmasının düşünülmesini öneriyoruz.

Article Details

The effect of astaxanthin on amiodarone induced cardiac tissue damage in rat

Authors:

Özlem Kara | Asuman Kilitci

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.194-199

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282245

pISSN:

2602-3032

Amiodarone

astaxanthin

rat

cardiac tissue

toxicity

Amiodaron

astaksantin

sıçan

kalp dokusu

toksisite

Issues

Article Details

Authors: Özlem Kara | Asuman Kilitci

Publisher: Cukurova University

Main Topics: Klinik Tıp Bilimleri

Journal: Cukurova Medical Journal Vol.48 Issue 1, pp.194-199

Document Type: Article

Publication Date: 3/2023

Document Language: English

Document ID (Org No.): 2001282245

pISSN: 2602-3032

Issues

Authors:

Özlem Kara | Asuman Kilitci

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.194-199

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282245

pISSN:

2602-3032