Relation of Cardiac Dysfunction to Thyroid Stimulating Hormone in Children with Down Syndrome

Mohamed E. Mowafy; Omneya I. Youssef; Heba S. Abd Elkhalek

doi:10.12816/0049344

Article Details

Relation of Cardiac Dysfunction to Thyroid Stimulating Hormone in Children with Down Syndrome

Authors:

Mohamed E. Mowafy | Omneya I. Youssef | Heba S. Abd Elkhalek

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2017 Vol.34 Issue 3-4, pp.145-156

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

124154

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0049344

Descriptors:

Keywords:

Abstract:

 Background: Down syndrome (DS) is the most common autosomal chromosomal anomaly. It may be associated with congenital heart disease (CHD) and various thyroid abnormalities.
Objective: To evaluate cardiac functions in relation to the thyroid profile in patients with DS.
Subjects and Methods: 100 consecutive patients with DS recruited from genetics clinic were enrolled, their ages ranged from 9 to 264 months. Free T4, TSH levels and thyroid antibodies (anti-thyroglobulin and anti-peroxidase) were measured, M mode, 2D, colour pulsed, continuous wave Doppler and tissue Doppler echocardiography were done.
Results: Subclinical hypothyroidism was detected in 8% of DS patients. 59 % of patients had left ventricular (LV) diastolic dysfunction and 18% had right ventricle (RV) diastolic dysfunction. There was statistically significant difference between patients with and without LV diastolic dysfunction regarding TSH. There was a significant positive correlation between TSH level and E wave at tricuspid annulus
Conclusion: Subclinical hypothyroidism was found in 8% of our DS patients, 59 % of patients had LV diastolic dysfunction and 18% had RV diastolic dysfunction.

Article Details

Relation of Cardiac Dysfunction to Thyroid Stimulating Hormone in Children with Down Syndrome

Authors:

Mohamed E. Mowafy | Omneya I. Youssef | Heba S. Abd Elkhalek

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2017 Vol.34 Issue 3-4, pp.145-156

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

124154

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0049344

Descriptors:

PAEDIATRICS

THYROID HORMONES

THYROID GLAND

HEART DISEASES

DOWN'S SYNDROME

DISTORTION

CHILDREN

Cardiac Abnormalities

Thyroid Dysfunctions

Down Syndrome

Issues

Article Details

Authors: Mohamed E. Mowafy | Omneya I. Youssef | Heba S. Abd Elkhalek

Publisher: Ain Shams University : Egyptian Paediatric Society

Main Topics: Medicine

Journal: Egyptian Journal of Pediatrics 2017 Vol.34 Issue 3-4, pp.145-156

Document Type: Article

Publication Date: 12/2017

Document Language: English

Document ID (Org No.): 124154

Frequency: Quarterly

pISSN: 16871677

DOI: 10.12816/0049344

Descriptors:

Issues

Authors:

Mohamed E. Mowafy | Omneya I. Youssef | Heba S. Abd Elkhalek

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2017 Vol.34 Issue 3-4, pp.145-156

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

124154

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0049344