Glucocortıcoıds: As A Clınıcıan We Use Much, We Know Less

Alişan YILDIRAN; Aynur DÜZGÜN; Recep SANCAK

Article Details

Glucocortıcoıds: As A Clınıcıan We Use Much, We Know Less

Authors:

Alişan YILDIRAN | Aynur DÜZGÜN | Recep SANCAK

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2009 Vol.26 Issue 3, pp.102-106

Document Type:

Article

Publication Date:

12/2010

Document Language:

English

Document ID (Org No.):

2000509870

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483

Abstract:

 

Glucocorticoids (GC) are frequently used important drugs in clinical practice of pediatrics. As well as, they have important physiologic functions; they have immune suppressive, anti-inflammatory and anti-allergic effects that they exert on primary and secondary immune cells, tissues and organs. Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGR); secondary non-genomic effects which are also initiated by the cGR; membrane-bound glucocorticoid receptor (mGR)-mediated non-genomic effects and finally non-specific, non-genomic effects caused by interactions with cellular membranes. Mechanisms of GR action are transactivation (GR binds to a related element in the promoter region of GC sensitive genes, inducing gene transcription) and transrepression (GR binds to a negative related element in a promoter region of GC-regulated genes that inhibit gene transcription by interfering with the binding of activating transcription factors). The underlying molecular mechanisms for their side effects are complex and frequently only partly understood. Recent data suggest that certain side effects are predominantly mediated via transactivation (e.g., diabetes, glaucoma), whereas others are predominantly mediated via transrepression (e.g., suppression of the hypothalamic-pituitary-adrenal axis). In this review, we aimed to look at new molecular mechanisms of effects and side effects in relationship with apoptosis and caveolin, intracellular transport and endoplasmic reticulum stress, resistance mechanisms and new drugs developed based on these topics of GCs.

Article Details

Glucocortıcoıds: As A Clınıcıan We Use Much, We Know Less

Authors: Alişan YILDIRAN | Aynur DÜZGÜN | Recep SANCAK

Publisher: Ondokuz Mayıs University

Main Topics: Promotion of health

Journal: Journal of Experimental and Clinical Medicine 2009 Vol.26 Issue 3, pp.102-106

Document Type: Article

Publication Date: 12/2010

Document Language: English

Document ID (Org No.): 2000509870

Frequency: Quarterly

eISSN: 1309-5129

pISSN: 1309-4483

Issues

Authors:

Alişan YILDIRAN | Aynur DÜZGÜN | Recep SANCAK

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2009 Vol.26 Issue 3, pp.102-106

Document Type:

Article

Publication Date:

12/2010

Document Language:

English

Document ID (Org No.):

2000509870

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483