Nasal Carriage of Superantigen Producing Staphylococcus Aureus and Its Role in Pathogenesis of Allergic Rhinitis and Bronchial Asthma

Ensaf A. Azzazy; Hossam A. Aziz; Maha K. Gohar; Reham H. Anis

doi:10.12816/0030402

Article Details

Nasal Carriage of Superantigen Producing Staphylococcus Aureus and Its Role in Pathogenesis of Allergic Rhinitis and Bronchial Asthma

Authors:

Ensaf A. Azzazy | Hossam A. Aziz | Maha K. Gohar | Reham H. Anis

Publisher:

The Egyptian Society of Medical Microbiology

Main Topics:

Medicine

Journal:

The Egyptian Journal of Medical Microbiology 2015 Vol.24 Issue 4, pp.105-111

Document Type:

Article

Publication Date:

10/2015

Document Language:

English

Document ID (Org No.):

92756

Frequency:

Quarterly

pISSN:

11102179

DOI:

10.12816/0030402

Descriptors:

Keywords:

Abstract:

 Staphylococcal enterotoxins can act as allergens and stimulate production of specific IgE with subsequent development of allergic manifestations. In addition, they act as superantigens that induce cytokine secretion with more increase of IL-4/IFN-γ ratio causing augmentation of allergic reactions. Herein we tested the hypothesis that exposure to Staphylococccus aureus and its enterotoxins induces immunological changes that contribute to the pathogenesis of allergic rhinitis and bronchial asthma. This study included 45 air way allergic patients, and 45 controls. The following were done: intradermal allergy skin testing, invitro effect of staphylococcal enterotoxin B (SEB) on cytokine secretion from separated peripheral blood mononuclear cells, detection of nasal carriage of S. aureus and its enterotoxin production by ELISA & serum levels of total IgE, SEB-specific IgE and eosinophil cationic protein (ECP) were measured. We found that nasal carriage of enterotoxin producing S. aureus in allergic patients was significantly higher than in control. Blood eosinophilia, total IgE& ECP levels were significantly higher in S. aureus nasal carrier than non-carrier patients. On in vitro exposure of PBMCs to (SEB), IFN-γ secretion was significantly less in patients than control and IL-4 secretion was significantly more in patients than control. SEB-specific IgE was detected in 15.6% of patients & not detected in control. There was a significant positive correlation between SEB-specific IgE level in patients and markers of severity of allergic reaction including blood eosinophilia, ECP and total IgE level. This study suggests that nasal carriage of enterotoxin producing S. aureus has a potential role in the development and severity of allergic airway diseases.

Article Details

Nasal Carriage of Superantigen Producing Staphylococcus Aureus and Its Role in Pathogenesis of Allergic Rhinitis and Bronchial Asthma

Authors:

Ensaf A. Azzazy | Hossam A. Aziz | Maha K. Gohar | Reham H. Anis

Publisher:

The Egyptian Society of Medical Microbiology

Main Topics:

Medicine

Journal:

The Egyptian Journal of Medical Microbiology 2015 Vol.24 Issue 4, pp.105-111

Document Type:

Article

Publication Date:

10/2015

Document Language:

English

Document ID (Org No.):

92756

Frequency:

Quarterly

pISSN:

11102179

DOI:

10.12816/0030402

Descriptors:

NASAL SECRETION

SUPERANTIGENS

STAPHYLOCOCCUS

PATHOGENESIS

RHINITIS

ASTHMA

Nasal Carriage

Staphylococcus Aureus

Superantigen

Enterotoxin

Allergic Rhinitis

Bronchial Asthma

Issues

Article Details

Authors: Ensaf A. Azzazy | Hossam A. Aziz | Maha K. Gohar | Reham H. Anis

Publisher: The Egyptian Society of Medical Microbiology

Main Topics: Medicine

Journal: The Egyptian Journal of Medical Microbiology 2015 Vol.24 Issue 4, pp.105-111

Document Type: Article

Publication Date: 10/2015

Document Language: English

Document ID (Org No.): 92756

Frequency: Quarterly

pISSN: 11102179

DOI: 10.12816/0030402

Descriptors:

Issues

Authors:

Ensaf A. Azzazy | Hossam A. Aziz | Maha K. Gohar | Reham H. Anis

Publisher:

The Egyptian Society of Medical Microbiology

Main Topics:

Medicine

Journal:

The Egyptian Journal of Medical Microbiology 2015 Vol.24 Issue 4, pp.105-111

Document Type:

Article

Publication Date:

10/2015

Document Language:

English

Document ID (Org No.):

92756

Frequency:

Quarterly

pISSN:

11102179

DOI:

10.12816/0030402