Hyperhomocysteinemia in HIV-Infected Individuals : Correlation of a Frequent Prothrombotic Factor with CD4 + Cell Count

Abdollahi , Alireza; Shoar , Tahereh Sanaei

doi:10.5001/omj.2012.50

Article Details

Hyperhomocysteinemia in HIV-Infected Individuals : Correlation of a Frequent Prothrombotic Factor with CD4 + Cell Count

Authors:

Abdollahi , Alireza | Shoar , Tahereh Sanaei

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2012 vol.27 Issue 3, pp.224-227

Document Type:

Article

Publication Date:

5/2012

Document Language:

English

Document ID (Org No.):

19166

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2012.50

Descriptors:

Keywords:

Abstract:

 Objective: This study was aimed at providing an analysis of thecorrelation between CD4/CD8 counts and some coagulationfactors in HIV-Positive Iranian patients.Methods: A case-control study on 58 HIV-infected patientsand control group (58 healthy individuals). Patients and controlswere matched for sex and age. In this study, several bloodparameters were measured in 58 HIV-infected patients andthe controls. Laboratory data were then measured includinghemoglobin, platelets, homocysteine, serum levels of IgM and IgGantiphospholipid antibodies (aPL), IgM and IgG anticardiolipinantibotdies (aCL), and CD4+ and CD8+ cell count.Results: The HIV-infected patients, compared to healthy controls,showed a significant decline in platelets, CD4 count and CD8count (p<0.0001), and an increase of homocysteine (p<0.0001)and IgG aPL levels (p<0.0001). No statistical difference was foundbetween patients with CD4 count ≤200 and CD4 count >200 inthe evaluated variables.Conclusion: The results showed that thrombophilic abnormalityin the form of hyperhomocysteinemia is more frequent in HIVinfectedpatients and should be considered by clinicians in viewof an early diagnosis of the hypercoagulability state to preventthrombotic complications.

Article Details

Hyperhomocysteinemia in HIV-Infected Individuals : Correlation of a Frequent Prothrombotic Factor with CD4 + Cell Count

Authors:

Abdollahi , Alireza | Shoar , Tahereh Sanaei

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2012 vol.27 Issue 3, pp.224-227

Document Type:

Article

Publication Date:

5/2012

Document Language:

English

Document ID (Org No.):

19166

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2012.50

Descriptors:

HIV

COAGULATION

THROMBOSIS

DIAGNOSIS

IRAN

CD4/CD8 Counts

Coagulation Factors

HIVPositive Patients

Issues

Article Details

Authors: Abdollahi , Alireza | Shoar , Tahereh Sanaei

Publisher: Oman Medical Specialty Board

Main Topics: Medicine

Journal: Oman Medical Journal 2012 vol.27 Issue 3, pp.224-227

Document Type: Article

Publication Date: 5/2012

Document Language: English

Document ID (Org No.): 19166

Frequency: Bi-Monthly

eISSN: 20705204

pISSN: 1999768X

DOI: 10.5001/omj.2012.50

Descriptors:

Issues

Authors:

Abdollahi , Alireza | Shoar , Tahereh Sanaei

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2012 vol.27 Issue 3, pp.224-227

Document Type:

Article

Publication Date:

5/2012

Document Language:

English

Document ID (Org No.):

19166

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2012.50