The Effect of Vitamin D Levels on Inflammation in Patients With Chronic Renal Failure

Nilüfer BULUT; Mehmet TAŞKAPAN; Hülya TAŞKAPAN

Article Details

The Effect of Vitamin D Levels on Inflammation in Patients With Chronic Renal Failure

Authors:

Nilüfer BULUT | Mehmet TAŞKAPAN | Hülya TAŞKAPAN

Publisher:

E-Journal of New World Sciences Academy

Main Topics:

Promotion of health

Journal:

Medical Sciences 2020 Vol.15 Issue 4, pp.166-178

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2000827182

Frequency:

Quarterly

eISSN:

1308-7312

Keywords:

Abstract:

 

It is suggested that a number of environmental and genetic factors trigger the formation of progressive kidney damage and complications. One of these factors is inflammation, it occurs as a result of a series of mechanisms included within a number of cytokines. Vitamin-D, IL-6, PCT and hs-CRP are also valuable biomarkers in terms of mortality in dialysis patients in this sense. Vitamin D deficiency is common in patients with chronic kidney disease (CKD)and is associated with inflammation. In recent years, some randomized controlled trials have revealed the effect of Vitamin D on inflammation in CKD patients, but the results are conflicting. The aim of our study is to investigate the relationship between Vitamin D, high-sensitivity C Reactive Protein (hs-CRP), procalcitonin and IL-6, and to evaluate the relation of Vitamin D levels with inflammation in PD patients, HD patients and controls. This study was carried on with 40 patients receiving on hemodialysis treatment, 40 patients receiving peritoneal treatment with renal failure disease and with a control group consisting of 40 healthy individuals. Vitamin D levels were measured by HPLC, PCT and IL-6 levels were measured by chemiluminescent method, hs-CRP is measured by nephelometric method. For Vitamin D, there was no differences between the groups. For PCT, there was a significant difference between all groups. For IL-6, while there was no difference between peritoneal and hemodialysis groups, a significant difference was determined between the peritoneal dialysis and control groups. For hs-CRP, there was a significant difference among all groups. While correlation was found between serum PCT levels with  IL-6 and hs-CRP, no correlations were found between serum PCT with Vitamin D levels. Although a correlation was found between serum IL-6 levels and hs-CRP, no correlation was detected between serum IL-6 and Vitamin D levels. No correlations were detected between Vitamin D andPCT, IL-6 and hs-CRP.

Article Details

The Effect of Vitamin D Levels on Inflammation in Patients With Chronic Renal Failure

Authors:

Nilüfer BULUT | Mehmet TAŞKAPAN | Hülya TAŞKAPAN

Publisher:

E-Journal of New World Sciences Academy

Main Topics:

Promotion of health

Journal:

Medical Sciences 2020 Vol.15 Issue 4, pp.166-178

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2000827182

Frequency:

Quarterly

eISSN:

1308-7312

Hemodialysis

High Sensitivity C-Reactive Protein

Interleukin-6

Peritoneal Dialysis

Procalcitonin

Vitamin D

Issues

Article Details

The Effect of Vitamin D Levels on Inflammation in Patients With Chronic Renal Failure

Authors: Nilüfer BULUT | Mehmet TAŞKAPAN | Hülya TAŞKAPAN

Publisher: E-Journal of New World Sciences Academy

Main Topics: Promotion of health

Journal: Medical Sciences 2020 Vol.15 Issue 4, pp.166-178

Document Type: Article

Publication Date: 10/2020

Document Language: English

Document ID (Org No.): 2000827182

Frequency: Quarterly

eISSN: 1308-7312

Hemodialysis

High Sensitivity C-Reactive Protein

Interleukin-6

Peritoneal Dialysis

Procalcitonin

Vitamin D

Issues

Authors:

Nilüfer BULUT | Mehmet TAŞKAPAN | Hülya TAŞKAPAN

Publisher:

E-Journal of New World Sciences Academy

Main Topics:

Promotion of health

Journal:

Medical Sciences 2020 Vol.15 Issue 4, pp.166-178

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2000827182

Frequency:

Quarterly

eISSN:

1308-7312