Effect of Benzene on Drug Metabolizing Enzyme Activities of Lung and Liver Microsomes

Emel Arınç

Article Details

Effect of Benzene on Drug Metabolizing Enzyme Activities of Lung and Liver Microsomes

Authors:

Emel Arınç

Publisher:

Islamic World Academy of Sciences (IAS)

Journal:

Medical Journal of Islamic World Academy of Sciences Vol.1 Issue 1, pp.31-34

Document Type:

Article

Publication Date:

1/1988

Document Language:

English

Document ID (Org No.):

2001937093

pISSN:

2415-1300

Keywords:

Abstract:

 In vivo treatment of rabbits with benzene (880 mg/kg, s. c., 3 days) caused 7. I-fold increase in hydroxylation of p-nitrophenol to 4-nitrocatechol in liver microsomes. A 3.7 fold increase was also observed in liver aniline 4- hydroxylation activities. Benzene treatment did not cause any significant changes on drug metabolizing enzyme activities of lung microsomes. Although benzene treatment did not change cytochrome P-450 contents of lung and liver microsomes, it caused 1 nm spectral shift in the absorption maxima of CO difference spectrum of the dithionote reduced liver cytochrome P-450 forming cytochrome P-451.

Article Details

Effect of Benzene on Drug Metabolizing Enzyme Activities of Lung and Liver Microsomes

Authors:

Emel Arınç

Publisher:

Islamic World Academy of Sciences (IAS)

Journal:

Medical Journal of Islamic World Academy of Sciences Vol.1 Issue 1, pp.31-34

Document Type:

Article

Publication Date:

1/1988

Document Language:

English

Document ID (Org No.):

2001937093

pISSN:

2415-1300

Benzene

drug metabolizing enzymes

mixed-function oxideses

microsomes

benzphetamine N-demethylase

aniline 4-hydroxylase

P-nitrophenol hydroxylase

cytochrome P-450

Issues

Article Details

Authors: Emel Arınç

Publisher: Islamic World Academy of Sciences (IAS)

Journal: Medical Journal of Islamic World Academy of Sciences Vol.1 Issue 1, pp.31-34

Document Type: Article

Publication Date: 1/1988

Document Language: English

Document ID (Org No.): 2001937093

pISSN: 2415-1300

Issues

Authors:

Emel Arınç

Publisher:

Islamic World Academy of Sciences (IAS)

Journal:

Medical Journal of Islamic World Academy of Sciences Vol.1 Issue 1, pp.31-34

Document Type:

Article

Publication Date:

1/1988

Document Language:

English

Document ID (Org No.):

2001937093

pISSN:

2415-1300