Assessment of Microvessels Density and Inflammatory Status in Oral Lichen Planus

Ban F. Al- Drobie

doi:10.12816/0015101

Article Details

Assessment of Microvessels Density and Inflammatory Status in Oral Lichen Planus

Authors:

Ban F. Al- Drobie

Publisher:

College of Dentistry : University of Baghdad

Main Topics:

Medicine

Journal:

Journal of Baghdad College of Dentistry 2013 Vol.25 Issue Speacial Issue 1, pp.43-47

Document Type:

Article

Publication Date:

6/2013

Document Language:

English

Document ID (Org No.):

71067

Frequency:

Quarterly

eISSN:

23115270

pISSN:

16800087

DOI:

10.12816/0015101

Descriptors:

Keywords:

Abstract:

 Background: Oral lichen planus (OLP) is a chronic inflammatory disease with an autoimmune inflammatorypathogenesis. The purpose of this study was to evaluate the role of angiogenesis in the pathogenesis of OLP, usingCD34 stain to highlight the blood vessels for measuring the microvessel density (MVD) as well as to evaluate therelation of this marker with the degree of inflammationMaterials and Methods: Immunohistochemical (IHC) staining technique was used to evaluate angiogenesis usingCD34 in 46 paraffin blocks 10 of them obtained from normal mucosa and 36 from cases diagnosed as lichen planus ,20 of them diagnosed as Reticular type while 16 as erosive type. Severity of inflammation was divided into mild,moderate and severe according to the number of mononuclear cell infiltrate.Results: The mean MVD as determined by the mean number of CD34 positive vessels in hot areas for OLP group washigher 39.2 (31.9 for reticular group & 48.375 for erosive group), whereas the mean MVD for control group 19.5 so thatthere was statistically significant difference between OLP group and the control group (p value<0.001). Regardingthe severity of inflammation mean MVD was significantly increased as the degree of inflammation increased ( pvalue<0.001).Conclusion: Angiogenesis may be an integral component associated with the development of the OLP

Article Details

Assessment of Microvessels Density and Inflammatory Status in Oral Lichen Planus

Authors:

Ban F. Al- Drobie

Publisher:

College of Dentistry : University of Baghdad

Main Topics:

Medicine

Journal:

Journal of Baghdad College of Dentistry 2013 Vol.25 Issue Speacial Issue 1, pp.43-47

Document Type:

Article

Publication Date:

6/2013

Document Language:

English

Document ID (Org No.):

71067

Frequency:

Quarterly

eISSN:

23115270

pISSN:

16800087

DOI:

10.12816/0015101

Descriptors:

INFLAMMATORY DISEASES

ENDOTHELIAL CELLS

LYMPHOCYTES

ANGIOGENESIS

MOUTH DISEASES

DENTISTRY

Oral Lichen Planus

Angiogenesis

CD34

Microvesels Density

Issues

Article Details

Authors: Ban F. Al- Drobie

Publisher: College of Dentistry : University of Baghdad

Main Topics: Medicine

Journal: Journal of Baghdad College of Dentistry 2013 Vol.25 Issue Speacial Issue 1, pp.43-47

Document Type: Article

Publication Date: 6/2013

Document Language: English

Document ID (Org No.): 71067

Frequency: Quarterly

eISSN: 23115270

pISSN: 16800087

DOI: 10.12816/0015101

Descriptors:

Issues

Authors:

Ban F. Al- Drobie

Publisher:

College of Dentistry : University of Baghdad

Main Topics:

Medicine

Journal:

Journal of Baghdad College of Dentistry 2013 Vol.25 Issue Speacial Issue 1, pp.43-47

Document Type:

Article

Publication Date:

6/2013

Document Language:

English

Document ID (Org No.):

71067

Frequency:

Quarterly

eISSN:

23115270

pISSN:

16800087

DOI:

10.12816/0015101