Antiapototic Effect of Captopril in Cisplatin-Induced Kidney Injury in Rats

Amany M. Gad; Ola M. Abd El-Raouf; Bahia M. El-Sayeh; Hala M. Fawzy; Dalaal M. Abdallah

doi:10.12816/0033767

Article Details

Antiapototic Effect of Captopril in Cisplatin-Induced Kidney Injury in Rats

Authors:

Amany M. Gad | Ola M. Abd El-Raouf | Bahia M. El-Sayeh | Hala M. Fawzy | Dalaal M. Abdallah

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2016 Vol.65, pp.573-582

Document Type:

Article

Publication Date:

10/2016

Document Language:

English

Document ID (Org No.):

97189

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0033767

Descriptors:

Keywords:

Abstract:

 Aim of the work: captopril protects against cisplatin induced nephrotoxicitity; however its potential modulatory effect on hemeoxygenase (HO)-1, antioxidants, as well as inflammatory and apoptotic markers has not yet been verified.
Materials and methods: male Sprague-Dawley rats were divided into control (saline), cisplatin (5 mg/kg; i.p), and captopril (60 and 100 mg/kg) given 5 days before and after cisplatin (5 mg/kg; i.p) treatment. Results :five-day pre- and post-treatment with captopril (60 and 100 mg/kg; i.p), for a total of 10 days, dose dependently, reduced blood urea nitrogen, as well as serum creatinine and gamma glutamyl transferase, but serum albumin and total protein levels were increased. Captopril restored renal pro-oxidant/antioxidant balance by activating glutathione peroxidase, catalase and superoxide dismutase, and boosting the renal glutathione content. These effects were accompanied by the reduction in serum and/or renal HO-1, tumor necrosis factor-α, monocyte chemoattractant protein-1, nitric oxide, endothelin-1 and caspase-3. Microscopically, captopril especially at 100 mg/kg dose level, prevented cisplatin-induced degenerative changes and inflammatory cell infiltration in the kidney. Conclusion: captopril protects against cisplatin nephrotoxicity by its antioxidant, antiinflammatory and antiapoptotic potentials.

Article Details

Antiapototic Effect of Captopril in Cisplatin-Induced Kidney Injury in Rats

Authors:

Amany M. Gad | Ola M. Abd El-Raouf | Bahia M. El-Sayeh | Hala M. Fawzy | Dalaal M. Abdallah

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2016 Vol.65, pp.573-582

Document Type:

Article

Publication Date:

10/2016

Document Language:

English

Document ID (Org No.):

97189

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0033767

Descriptors:

ENZYME INHIBITORS

ANTINEOPLASTIC DRUGS

INFLAMMATION

KIDNEYS

RATS

LABORATORY ANIMALS

PHARMACOLOGY

Captopril

Cisplatin

Renoprotection

Apoptosis

Inflammation

Issues

Article Details

Authors: Amany M. Gad | Ola M. Abd El-Raouf | Bahia M. El-Sayeh | Hala M. Fawzy | Dalaal M. Abdallah

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2016 Vol.65, pp.573-582

Document Type: Article

Publication Date: 10/2016

Document Language: English

Document ID (Org No.): 97189

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

DOI: 10.12816/0033767

Descriptors:

Issues

Authors:

Amany M. Gad | Ola M. Abd El-Raouf | Bahia M. El-Sayeh | Hala M. Fawzy | Dalaal M. Abdallah

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2016 Vol.65, pp.573-582

Document Type:

Article

Publication Date:

10/2016

Document Language:

English

Document ID (Org No.):

97189

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0033767