The Role of Activin-A in the Etiopathogenesis of Nasal Polyposis

Hakan DAĞISTAN; Mete Kaan BOZKURT; Çağdaş ELSÜRER; Pınar KARABAĞLI

doi:https://doi.org/10.26650/Tr-ENT.2021.994774

Article Details

The Role of Activin-A in the Etiopathogenesis of Nasal Polyposis

Authors:

Hakan DAĞISTAN | Mete Kaan BOZKURT | Çağdaş ELSÜRER | Pınar KARABAĞLI

Publisher:

Istanbul University

Main Topics:

Surgery & related medical specialties

Journal:

The Turkish Journal of Ear Nose and Throat 2021 Vol.31 Issue 3, pp.60-65

Document Type:

Article

Publication Date:

11/2021

Document Language:

English

Document ID (Org No.):

2000805594

Frequency:

Quarterly

eISSN:

2602-4837

DOI:

https://doi.org/10.26650/Tr-ENT.2021.994774

Abstract:

 


Objective:  Nasal  polyposis  (NP)  is  defined  as  persistent  inflammation  of  the  sinonasal  mucosa  intractable  to  medical  and  surgical  treatment.  Activin-A, is a pleiotropic cytokine in the transforming growth factor-b (TGF-β) superfamily and was shown to orchestrate the allergic inflammation in asthma via suppression of T helper-2 (Th2) cells, induction of regulatory T cells, and tissue repair. The purpose of this study was to investigate the role of the activin-A in pathophysiology of NP.

Materials and Methods: According to the European Rhinosinusitis and Nasal Polyp criteria, 50 patients and 24 healthy subjects were included in the study. There were no significant differences across age and gender between the 2 groups (p>0.05). Samples from patients with NP (n=50; 11 women,  39  men)  were  acquired  during  endoscopic  sinus  surgeries.  Middle  turbinate  specimens  from  patients  without  sinus  disease  and  who  were undergoing septoplasty were collected as controls (n=24; 3 women, 21 men).

Results: Immunohistochemical staining with activin-A showed an increase in the staining intensity, number of glands and inflammatory cells in polyp specimens compared to healthy nasal mucosa. In contrast, no differences were found in fibroblasts and vascular density.

Conclusion: We evaluated the expression of activin-A in NP tissue, which showed a slightly elevated expression compared to the controls. This might  support  the  possible  role  of  activin-A  in  the  pathophysiology  of  NP.  Clearer  elucidation  of  the  roles  of  activin-A  and  other  mediators  in  tissue remodeling in NP may ensure more accurate targets for treatment and prevention of relapse.

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Article Details

The Role of Activin-A in the Etiopathogenesis of Nasal Polyposis

Authors: Hakan DAĞISTAN | Mete Kaan BOZKURT | Çağdaş ELSÜRER | Pınar KARABAĞLI

Publisher: Istanbul University

Main Topics: Surgery & related medical specialties

Journal: The Turkish Journal of Ear Nose and Throat 2021 Vol.31 Issue 3, pp.60-65

Document Type: Article

Publication Date: 11/2021

Document Language: English

Document ID (Org No.): 2000805594

Frequency: Quarterly

eISSN: 2602-4837

DOI: https://doi.org/10.26650/Tr-ENT.2021.994774

Issues

Authors:

Hakan DAĞISTAN | Mete Kaan BOZKURT | Çağdaş ELSÜRER | Pınar KARABAĞLI

Publisher:

Istanbul University

Main Topics:

Surgery & related medical specialties

Journal:

The Turkish Journal of Ear Nose and Throat 2021 Vol.31 Issue 3, pp.60-65

Document Type:

Article

Publication Date:

11/2021

Document Language:

English

Document ID (Org No.):

2000805594

Frequency:

Quarterly

eISSN:

2602-4837

DOI:

https://doi.org/10.26650/Tr-ENT.2021.994774