Ameliorative effects of melatonin on intestinal oxidative damage in streptozotocin-induced diabetic rats

Zatiye Ayça ÇEVİKELLİ YAKUT; Gizem Buse AKÇAY; Özge ÇEVİK; Göksel ŞENER

Article Details

Ameliorative effects of melatonin on intestinal oxidative damage in streptozotocin-induced diabetic rats

Authors:

Zatiye Ayça ÇEVİKELLİ YAKUT | Gizem Buse AKÇAY | Özge ÇEVİK | Göksel ŞENER

Publisher:

Istanbul University

Main Topics:

Pharmacology and therapeutics | Promotion of health

Journal:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.160-167

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000512907

Frequency:

Monthly

eISSN:

2587-2087

Abstract:

 

investigated. Methods: Male Sprague-Dawley rats were assigned into 5 groups (10 rats in each): Control, diabetes, diabetes+insulin, diabetes+melatonin, and diabetes+insulin+melatonin groups. Streptozotocin (60 mg/kg) was administered intraperitoneally to the rats to induce diabetes. At the end of 8 weeks of treatment, after blood glucose measurement and subsequent decapitation, glutathione (GSH) and malondialdehyde (MDA) levels and caspase-3, myeloperoxidase (MPO), and superoxide dismutase (SOD) activities in the intestinal tissue were investigated. Results: In diabetic animals, elevated blood glucose levels caused oxidant damage in the intestinal tissue that was demonstrated with increased MDA levels, caspase and MPO activities, and decreased GSH levels and SOD activities. Although melatonin demonstrated more significant results than insulin, separate administration of both melatonin and insulin improved the oxidative damage parameters compared to the diabetes group. In the combined treatment group, all parameters were back to control levels statistically more significant when compared with the treatment-alone. Conclusion: Melatonin has been shown to protect intestinal tissue from diabetic oxidant damage. With insulin treatment in type I diabetes, melatonin supplements may increase the quality of life through reducing complications.

Article Details

Ameliorative effects of melatonin on intestinal oxidative damage in streptozotocin-induced diabetic rats

Authors: Zatiye Ayça ÇEVİKELLİ YAKUT | Gizem Buse AKÇAY | Özge ÇEVİK | Göksel ŞENER

Publisher: Istanbul University

Main Topics: Pharmacology and therapeutics | Promotion of health

Journal: İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.160-167

Document Type: Article

Publication Date: 12/2020

Document Language: English

Document ID (Org No.): 2000512907

Frequency: Monthly

eISSN: 2587-2087

Issues

Authors:

Zatiye Ayça ÇEVİKELLİ YAKUT | Gizem Buse AKÇAY | Özge ÇEVİK | Göksel ŞENER

Publisher:

Istanbul University

Main Topics:

Pharmacology and therapeutics | Promotion of health

Journal:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.160-167

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000512907

Frequency:

Monthly

eISSN:

2587-2087