Application of FTIR Spectroscopy method for The Quantification of Ascorbic Acid in Bulk Materials and Pharmaceutical Formulation

Rihab Alhajjeh; Haifaa Al-Ali

doi:10.31351/vol32iss3pp186-194

Article Details

Application of FTIR Spectroscopy method for The Quantification of Ascorbic Acid in Bulk Materials and Pharmaceutical Formulation

Authors:

Rihab Alhajjeh | Haifaa Al-Ali

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 3, pp.186-194

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001363113

pISSN:

2521-3512

DOI:

10.31351/vol32iss3pp186-194

Keywords:

Abstract:

 The present study illustrates the potential using of Fourier Transform Infrared Spectroscopy (FT-IR) in pharmaceutical analysis. A simple, rapid, non-destructive, and green (FT-IR) spectroscopy method for quality control evaluation of Ascorbic acid was developed, using potassium bromide (KBr) as a matrix to quantify the drug in bulk pharmaceutical materials and AUC its dosage forms. The sample preparation was done by mixing and grinding for disk composition and without using organic solvents. Absorbance obtained for the carbon-carbon band (C=C) located at the range (1600-1700) cm-1 was used to develop a calibration curve based on the AUC measurements. Method had been validated according to the International Conference on Harmonization (ICH) guidelines. Linearity, accuracy, precision, robustness, LOD and LOQ were evaluated and showed acceptable results for method validation in the concentration range of (2 - 12.5 mg). The validated method was able to apply for the quality control analysis of Ascorbic Acid raw materials and pharmaceutical dosage forms.

Article Details

Application of FTIR Spectroscopy method for The Quantification of Ascorbic Acid in Bulk Materials and Pharmaceutical Formulation

Authors:

Rihab Alhajjeh | Haifaa Al-Ali

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 3, pp.186-194

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001363113

pISSN:

2521-3512

DOI:

10.31351/vol32iss3pp186-194

Ascorbic acid

Effervescent tablets

Fourier transform infrard spectroscopy

Quantative analysis

Validation

Issues

Article Details

Application of FTIR Spectroscopy method for The Quantification of Ascorbic Acid in Bulk Materials and Pharmaceutical Formulation

Authors: Rihab Alhajjeh | Haifaa Al-Ali

Publisher: University of Baghdad

Journal: Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 3, pp.186-194

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001363113

pISSN: 2521-3512

DOI: 10.31351/vol32iss3pp186-194

Ascorbic acid

Effervescent tablets

Fourier transform infrard spectroscopy

Quantative analysis

Validation

Issues

Authors:

Rihab Alhajjeh | Haifaa Al-Ali

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.32 Issue 3, pp.186-194

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001363113

pISSN:

2521-3512

DOI:

10.31351/vol32iss3pp186-194