THE EFFECT OF PHOTOTHERAPY TREATMENT ON OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN NEWBORNS

Nilufer Guzoglu; Üçler Kısa; Didem Aliefendioğlu

Article Details

THE EFFECT OF PHOTOTHERAPY TREATMENT ON OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN NEWBORNS

Authors:

Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher:

Kirikkale University

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.25 Issue 1, pp.16-22

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001285096

pISSN:

2148-9645

Keywords:

Abstract:

 Objective: A reason for oxidative stress is photodynamic reactions with phototherapy. It is thought that phototherapy changes cytokine production which leads to different effects on the immune system. The aim of this study is to investigate the effects of light-emitting diode LED phototherapy and conventional phototherapy on oxidative stress and inflammatory response in neonatal hyperbilirubinemia. Material and Methods: Thirty-term newborns treated with phototherapy were enrolled on the study group. The study group was divided into LED phototherapy n15 and conventional phototherapy n15 subgroups. The control group consisted of 30-term healthy newborns. Blood samples were taken before phototherapy, at the 24th hours of phototherapy and after phototherapy treatment. Bilirubin, malonaldehyde MDA, total oxidative stress TOS, total antioxidant capacity TAC, TNF- α, IL-6 and IL-8 levels were evaluated between groups. Results: There were no significant differences in MDA and TAC in the conventional phototherapy group both before and after phototherapy. However, TOS levels were significantly higher during and after phototherapy than before phototherapy in the conventional phototherapy group. In the same group, IL-8 levels were significantly higher during phototherapy than after phototherapy levels. Whereas, there were no significant differences in oxidative stress and inflammatory response parameters in the LED phototherapy group. Conclusion: While conventional phototherapy increases oxidative stress and acts at some stages of the inflammatory response, there are no effects of LED phototherapy on antioxidant defence systems and inflammatory response.

 Objective: A reason for oxidative stress is photodynamic reactions with phototherapy. It is thought that phototherapy changes cytokine production which leads to different effects on the immune system. The aim of this study is to investigate the effects of light-emitting diode LED phototherapy and conventional phototherapy on oxidative stress and inflammatory response in neonatal hyperbilirubinemia. Material and Methods: Thirty-term newborns treated with phototherapy were enrolled on the study group. The study group was divided into LED phototherapy n15 and conventional phototherapy n15 subgroups. The control group consisted of 30-term healthy newborns. Blood samples were taken before phototherapy, at the 24th hours of phototherapy and after phototherapy treatment. Bilirubin, malonaldehyde MDA, total oxidative stress TOS, total antioxidant capacity TAC, TNF- α, IL-6 and IL-8 levels were evaluated between groups. Results: There were no significant differences in MDA and TAC in the conventional phototherapy group both before and after phototherapy. However, TOS levels were significantly higher during and after phototherapy than before phototherapy in the conventional phototherapy group. In the same group, IL-8 levels were significantly higher during phototherapy than after phototherapy levels. Whereas, there were no significant differences in oxidative stress and inflammatory response parameters in the LED phototherapy group. Conclusion: While conventional phototherapy increases oxidative stress and acts at some stages of the inflammatory response, there are no effects of LED phototherapy on antioxidant defence systems and inflammatory response.

 Objective: A reason for oxidative stress is photodynamic reactions with phototherapy. It is thought that phototherapy changes cytokine production which leads to different effects on the immune system. The aim of this study is to investigate the effects of light-emitting diode LED phototherapy and conventional phototherapy on oxidative stress and inflammatory response in neonatal hyperbilirubinemia. Material and Methods: Thirty-term newborns treated with phototherapy were enrolled on the study group. The study group was divided into LED phototherapy n15 and conventional phototherapy n15 subgroups. The control group consisted of 30-term healthy newborns. Blood samples were taken before phototherapy, at the 24th hours of phototherapy and after phototherapy treatment. Bilirubin, malonaldehyde MDA, total oxidative stress TOS, total antioxidant capacity TAC, TNF- α, IL-6 and IL-8 levels were evaluated between groups. Results: There were no significant differences in MDA and TAC in the conventional phototherapy group both before and after phototherapy. However, TOS levels were significantly higher during and after phototherapy than before phototherapy in the conventional phototherapy group. In the same group, IL-8 levels were significantly higher during phototherapy than after phototherapy levels. Whereas, there were no significant differences in oxidative stress and inflammatory response parameters in the LED phototherapy group. Conclusion: While conventional phototherapy increases oxidative stress and acts at some stages of the inflammatory response, there are no effects of LED phototherapy on antioxidant defence systems and inflammatory response.

 Amaç: Oksidatif stresin bir nedeni fototerapi ile oluşan fotodinamik reaksiyonlardır. Fototerapinin bağışıklık sisteminde farklı etkilere yol açan sitokin üretimini değiştirdiği düşünülmektedir. Bu çalışmanın amacı, hiperbilirubinemik yenidoğanlarda ışık yayan diyot LED fototerapi ve konvansiyonel fototerapinin oksidatif stres ve inflamatuar yanıt üzerindeki etkilerini araştırmaktır. Gereç ve Yöntemler: Fototerapi ile tedavi edilen 30 term yenidoğan çalışma grubuna alındı. Çalışma grubu LED fototerapi n15 ve konvansiyonel fototerapi n15 alt gruplarına ayrıldı. Kontrol grubu 30 günlük sağlıklı yenidoğanlardan oluşturuldu. Fototerapi öncesi, fototerapinin 24. saati ve fototerapi tedavisi sonrası kan örnekleri alındı. Gruplar arasında bilirubin, malonaldehit MDA, toplam oksidatif stres TOS, toplam antioksidan kapasite TAC, TNF-α, IL-6 ve IL-8 düzeyleri değerlendirildi. Bulgular: Konvansiyonel fototerapi grubunda fototerapi öncesi ve sonrası MDA ve TAC açısından anlamlı fark yoktu. Bununla birlikte, fototerapi sırasında ve sonrasında TOS seviyeleri, konvansiyonel fototerapi grubunda fototerapi öncesine göre anlamlı derecede yüksekti. Aynı grupta IL-8 seviyeleri fototerapi sırasında fototerapi sonrası ile karşılaştırıldığında anlamlı derecede yüksekti. LED fototerapi grubunda ise oksidatif stres ve inflamatuar yanıt parametrelerinde farklılık yoktu. Sonuç: Konvansiyonel fototerapi oksidatif stresi artırırken ve inflamatuar yanıtın bazı aşamalarında etki gösterirken, LED fototerapinin antioksidan savunma sistemleri ve inflamatuar yanıt üzerinde herhangi bir etkisi gösterilememiştir.

Article Details

THE EFFECT OF PHOTOTHERAPY TREATMENT ON OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN NEWBORNS

Authors:

Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher:

Kirikkale University

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.25 Issue 1, pp.16-22

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001285096

pISSN:

2148-9645

Hyperbilirubinemia

inflammatory response

phototherapy

oxidative stress

Hiperbilirubinemi

inflamatuar yanıt

fototerapi

oksidatif stres

Issues

Article Details

Authors: Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher: Kirikkale University

Main Topics: Sağlık Kurumları Yönetimi

Journal: Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.25 Issue 1, pp.16-22

Document Type: Article

Publication Date: 4/2023

Document Language: English

Document ID (Org No.): 2001285096

pISSN: 2148-9645

Issues

Authors:

Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher:

Kirikkale University

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.25 Issue 1, pp.16-22

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001285096

pISSN:

2148-9645