BRCA 1 and 2 Mutations in Sudanese Secondary School Girls with Known Breast Cancer in Their Families

Ahmed M. Elnour; Abozer Y. Elderdery; Jeremy Mills; Babiker A. Mohammed; Daw ElbietAbdelaal; Abdelraheem Osman Mohamed; Kamal Eldin H. Elhassan; Abdel Hady A. Abdel Wahab; Alan Cooper

doi:10.12816/0005974

Article Details

BRCA 1 and 2 Mutations in Sudanese Secondary School Girls with Known Breast Cancer in Their Families

Authors:

Ahmed M. Elnour | Abozer Y. Elderdery | Jeremy Mills | Babiker A. Mohammed | Daw ElbietAbdelaal | Abdelraheem Osman Mohamed | Kamal Eldin H. Elhassan | Abdel Hady A. Abdel Wahab | Alan Cooper

Publisher:

Al-Qassim University

Main Topics:

Medicine

Journal:

International Journal of Health Sciences 2012 Vol.6 Issue 1, pp.63-71

Document Type:

Article

Publication Date:

1/2012

Document Language:

English

Document ID (Org No.):

52525

Frequency:

Tri-Annual

pISSN:

16583639

DOI:

10.12816/0005974

Descriptors:

Keywords:

Abstract:

 Objective: Breast cancer is a major cause of morbidity and mortality in women worldwide. In Sudan, it is the most commonlydiagnosed cancer. This study assesses the prevalence of BRCA1 and BRCA2 mutations among female students with a familyhistory of breast cancer, in secondary schools of Marawi Locality, Northern State, Sudan.Methods: From a survey of 2370 students, 67 cases (47 with family history and 20 controls) were analyzed for BRCA1 andBRCA2 mutations with a single-stranded conformation polymorphism (SSCP) mutation detection method applied to peripheralblood. Eighteen subjects knew of first degree female relatives with breast cancer, 23 with second degree female familymembers affected and 6 with related male sufferers. Twenty randomly selected girls from the remainder of the survey populationwith no known family history were also tested.Results: The breast cancer susceptibility genes BRCA1 and BRCA2 accounted, respectively, for 1.21% of responders or 51%of those claiming a family history. Mutations were found in 20% of the group selected with no family history. Only 2 BRCA 2mutations were found, both in girls with no known afflicted relatives. Six girls knew of male relatives with breast cancer; five ofthese girls carried mutant BRCA 1. Most of the BRCA1- mutations located to exon 11 fragments 11.9 and 11.1.Conclusion: The study indicates a high prevalence of genetically associated breast cancer in the Marawi locality suggesting aneed to focus on the two mutation sites in developing screening protocols for at least this area of Sudan.

Article Details

BRCA 1 and 2 Mutations in Sudanese Secondary School Girls with Known Breast Cancer in Their Families

Authors:

Ahmed M. Elnour | Abozer Y. Elderdery | Jeremy Mills | Babiker A. Mohammed | Daw ElbietAbdelaal | Abdelraheem Osman Mohamed | Kamal Eldin H. Elhassan | Abdel Hady A. Abdel Wahab | Alan Cooper

Publisher:

Al-Qassim University

Main Topics:

Medicine

Journal:

International Journal of Health Sciences 2012 Vol.6 Issue 1, pp.63-71

Document Type:

Article

Publication Date:

1/2012

Document Language:

English

Document ID (Org No.):

52525

Frequency:

Tri-Annual

pISSN:

16583639

DOI:

10.12816/0005974

Descriptors:

DISEASES

BREAST CANCER

MUTATION

DIAGNOSIS

MEDICAL EXAMINATION

SUDAN

Breast Cancer

BRCA 1

BRCA 2

Sudan

Schoolgirls

Issues

Article Details

Authors: Ahmed M. Elnour | Abozer Y. Elderdery | Jeremy Mills | Babiker A. Mohammed | Daw ElbietAbdelaal | Abdelraheem Osman Mohamed | Kamal Eldin H. Elhassan | Abdel Hady A. Abdel Wahab | Alan Cooper

Publisher: Al-Qassim University

Main Topics: Medicine

Journal: International Journal of Health Sciences 2012 Vol.6 Issue 1, pp.63-71

Document Type: Article

Publication Date: 1/2012

Document Language: English

Document ID (Org No.): 52525

Frequency: Tri-Annual

pISSN: 16583639

DOI: 10.12816/0005974

Descriptors:

Issues

Authors:

Ahmed M. Elnour | Abozer Y. Elderdery | Jeremy Mills | Babiker A. Mohammed | Daw ElbietAbdelaal | Abdelraheem Osman Mohamed | Kamal Eldin H. Elhassan | Abdel Hady A. Abdel Wahab | Alan Cooper

Publisher:

Al-Qassim University

Main Topics:

Medicine

Journal:

International Journal of Health Sciences 2012 Vol.6 Issue 1, pp.63-71

Document Type:

Article

Publication Date:

1/2012

Document Language:

English

Document ID (Org No.):

52525

Frequency:

Tri-Annual

pISSN:

16583639

DOI:

10.12816/0005974