Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Basima A. A. Saleem

doi:10.30526/32.3.2281

Article Details

Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Authors:

Basima A. A. Saleem

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.32 Issue 3, pp.43-55

Document Type:

Article

Publication Date:

9/2019

Document Language:

English

Document ID (Org No.):

2001377706

pISSN:

2521-3407

DOI:

10.30526/32.3.2281

Keywords:

Abstract:

 A spectrophotometric method is proposed for the determination of some drugs containing amino group such as mesalazine, metoclopramide and dopamine in pharmaceutical formulations. It was simple, precise, accurate, rapid, and based on the oxidation of each drug with chromate as an oxidizing agent in the presence of 1N hydrochloric acid. Then indigo carmine is reacted with residual chromate in the presence of a catalysis factor (sodium oxalate). Increasing in absorbance's value of the color system is proportional to the amount of the three drugs which is measured at the selected wavelength of 610 nm.
The proposed method is obeying Beer's law in the ranges of (1-40, 2-44 and 2-52) ppm for the concentration of mesalazine, metoclopramide and dopamine respectively. Molar absorptivity was 0.191Ã—104, 0.449Ã—104 and 0.191Ã—104 L.mol-1.cm-1 mesalazine, metoclopramide and dopamine respectively. While, Sandell's sensitivity index of 0.0806, 0.0667 and 0.0806 Î¼g.cm-2 mesalazine, metoclopramide and dopamine respectively.
The proposed spectrophotometric method has a good recovery when it is applied for the determination of the three drugs in pure form and pharmaceutical doses.

Article Details

Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Authors:

Basima A. A. Saleem

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.32 Issue 3, pp.43-55

Document Type:

Article

Publication Date:

9/2019

Document Language:

English

Document ID (Org No.):

2001377706

pISSN:

2521-3407

DOI:

10.30526/32.3.2281

Spectrophotometric oxidation-reduction reaction

Mesalazine

Metoclopramide

Dopamine

Issues

Article Details

Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Authors: Basima A. A. Saleem

Publisher: University of Baghdad

Journal: Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.32 Issue 3, pp.43-55

Document Type: Article

Publication Date: 9/2019

Document Language: English

Document ID (Org No.): 2001377706

pISSN: 2521-3407

DOI: 10.30526/32.3.2281

Spectrophotometric oxidation-reduction reaction

Mesalazine

Metoclopramide

Dopamine

Issues

Authors:

Basima A. A. Saleem

Publisher:

University of Baghdad

Journal:

Ibn AL-Haitham Journal For Pure and Applied Sciences Vol.32 Issue 3, pp.43-55

Document Type:

Article

Publication Date:

9/2019

Document Language:

English

Document ID (Org No.):

2001377706

pISSN:

2521-3407

DOI:

10.30526/32.3.2281