Y chromosome microdeletions in infertile Moroccan males: 10 years laboratory experience in AZF deletions

Brahim EL HOUATE; Zouhair ELKARHAT; Hicham CHAROUTE; Houda HARMAK; Salaheddine REDOUANE; Abdelhamid BARAKAT; Hassan ROUBA

Article Details

Y chromosome microdeletions in infertile Moroccan males: 10 years laboratory experience in AZF deletions

Authors:

Brahim EL HOUATE | Zouhair ELKARHAT | Hicham CHAROUTE | Houda HARMAK | Salaheddine REDOUANE | Abdelhamid BARAKAT | Hassan ROUBA

Publisher:

Moroccan Journal of Public Heath

Journal:

Moroccan Journal of Public Heath Vol.2 Issue 1, pp.50-55

Document Type:

Article

Publication Date:

7/2021

Document Language:

English

Document ID (Org No.):

2001843386

pISSN:

2658-8099

Keywords:

Abstract:

 Genetic causes of male infertility are abnormalities in chromosome numbers and/or structures, Y-chromosome deletions and gene mutations. Genetic screening of male infertility is rarely done in our country. The purpose of the study was to investigate the frequencies and types of Y chromosome microdeletions in infertile men, based on studies done in the Human Genetics Laboratory of the Pasteur Institute in Morocco.A total of 543 infertile men were screened for Y chromosome microdeletions.The prevalence of AZF Y-chromosome microdeletions among infertile men range from 3% to 10% depending on patients selected. The most frequent microdeletions were detected in the AZFc region, followed by AZFbc, AZFb, AZFa, AZFab.These results indicate the need for Y chromosome microdeletion screening for better management of infertile patients.We hope to encourage use of genetic diagnosis and also research in this field to initiate collaboration for clinical management and appropriate genetic diagnosis and counselling for male infertility.

Article Details

Y chromosome microdeletions in infertile Moroccan males: 10 years laboratory experience in AZF deletions

Authors:

Brahim EL HOUATE | Zouhair ELKARHAT | Hicham CHAROUTE | Houda HARMAK | Salaheddine REDOUANE | Abdelhamid BARAKAT | Hassan ROUBA

Publisher:

Moroccan Journal of Public Heath

Journal:

Moroccan Journal of Public Heath Vol.2 Issue 1, pp.50-55

Document Type:

Article

Publication Date:

7/2021

Document Language:

English

Document ID (Org No.):

2001843386

pISSN:

2658-8099

Genetic diagnosis

Male infertility

Y microdeletions

Moroccan population

Issues

Article Details

Y chromosome microdeletions in infertile Moroccan males: 10 years laboratory experience in AZF deletions

Authors: Brahim EL HOUATE | Zouhair ELKARHAT | Hicham CHAROUTE | Houda HARMAK | Salaheddine REDOUANE | Abdelhamid BARAKAT | Hassan ROUBA

Publisher: Moroccan Journal of Public Heath

Journal: Moroccan Journal of Public Heath Vol.2 Issue 1, pp.50-55

Document Type: Article

Publication Date: 7/2021

Document Language: English

Document ID (Org No.): 2001843386

pISSN: 2658-8099

Genetic diagnosis

Male infertility

Y microdeletions

Moroccan population

Issues

Authors:

Brahim EL HOUATE | Zouhair ELKARHAT | Hicham CHAROUTE | Houda HARMAK | Salaheddine REDOUANE | Abdelhamid BARAKAT | Hassan ROUBA

Publisher:

Moroccan Journal of Public Heath

Journal:

Moroccan Journal of Public Heath Vol.2 Issue 1, pp.50-55

Document Type:

Article

Publication Date:

7/2021

Document Language:

English

Document ID (Org No.):

2001843386

pISSN:

2658-8099