The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects

Adem Milletsever; Abdurrahman Gülal; Halil Aşçı

Article Details

The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects

Authors:

Adem Milletsever | Abdurrahman Gülal | Halil Aşçı

Publisher:

Süleyman Demirel University

Main Topics:

Brain and Nerve Surgery (Neurosurgery) | Thoracic Surgery | Medical Pharmacology | Chest Diseases

Journal:

Medical Journal of Süleyman Demirel University Vol.31 Issue 4, pp.332-338

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001335528

pISSN:

1300-7416

Keywords:

Abstract:

 Objective: Chest trauma-induced brain injury CTBI is caused by the formation of inflammatory cytokines in the lungs and blood. Cannabidiol CBD, a non-psychoactive agent, has antioxidant, anti-inflammatory, and antiapoptotic properties. In this study, we aimed to investigate the protective effects of CBD on CTBI. Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI 200 g weight drop on the anterior chest wall from a height of 1 meter, CTBICBD 5 mgkg, single dose intraperitoneally, and CBD. After 48 hours, rats were sacrificed under anesthesia, and brain tissues were placed in a 10 formaldehyde solution for histopathological and immunohistochemical examination. Results: In the CTBI group, hemorrhagic areas, tumor necrosis factor-alpha, caspase-3, and malondialdehyde expressions increased in histological and immunohistochemical examinations compared to the control group. CBD treatment reduced hemorrhagic areas and reversed immune expressions. Conclusion: Inflammation, apoptosis, and oxidative stress in brain tissue may develop in CTBI. These damages can be corrected with CBD treatment.

 Objective: Chest trauma-induced brain injury CTBI is caused by the formation of inflammatory cytokines in the lungs and blood. Cannabidiol CBD, a non-psychoactive agent, has antioxidant, anti-inflammatory, and antiapoptotic properties. In this study, we aimed to investigate the protective effects of CBD on CTBI. Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI 200 g weight drop on the anterior chest wall from a height of 1 meter, CTBICBD 5 mgkg, single dose intraperitoneally, and CBD. After 48 hours, rats were sacrificed under anesthesia, and brain tissues were placed in a 10 formaldehyde solution for histopathological and immunohistochemical examination. Results: In the CTBI group, hemorrhagic areas, tumor necrosis factor-alpha, caspase-3, and malondialdehyde expressions increased in histological and immunohistochemical examinations compared to the control group. CBD treatment reduced hemorrhagic areas and reversed immune expressions. Conclusion: Inflammation, apoptosis, and oxidative stress in brain tissue may develop in CTBI. These damages can be corrected with CBD treatment.

 Objective: Chest trauma-induced brain injury CTBI is caused by the formation of inflammatory cytokines in the lungs and blood. Cannabidiol CBD, a non-psychoactive agent, has antioxidant, anti-inflammatory, and antiapoptotic properties. In this study, we aimed to investigate the protective effects of CBD on CTBI. Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI 200 g weight drop on the anterior chest wall from a height of 1 meter, CTBICBD 5 mgkg, single dose intraperitoneally, and CBD. After 48 hours, rats were sacrificed under anesthesia, and brain tissues were placed in a 10 formaldehyde solution for histopathological and immunohistochemical examination. Results: In the CTBI group, hemorrhagic areas, tumor necrosis factor-alpha, caspase-3, and malondialdehyde expressions increased in histological and immunohistochemical examinations compared to the control group. CBD treatment reduced hemorrhagic areas and reversed immune expressions. Conclusion: Inflammation, apoptosis, and oxidative stress in brain tissue may develop in CTBI. These damages can be corrected with CBD treatment.

 Objective: Chest trauma-induced brain injury CTBI is caused by the formation of inflammatory cytokines in the lungs and blood. Cannabidiol CBD, a non-psychoactive agent, has antioxidant, anti-inflammatory, and antiapoptotic properties. In this study, we aimed to investigate the protective effects of CBD on CTBI. Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI 200 g weight drop on the anterior chest wall from a height of 1 meter, CTBICBD 5 mgkg, single dose intraperitoneally, and CBD. After 48 hours, rats were sacrificed under anesthesia, and brain tissues were placed in a 10 formaldehyde solution for histopathological and immunohistochemical examination. Results: In the CTBI group, hemorrhagic areas, tumor necrosis factor-alpha, caspase-3, and malondialdehyde expressions increased in histological and immunohistochemical examinations compared to the control group. CBD treatment reduced hemorrhagic areas and reversed immune expressions. Conclusion: Inflammation, apoptosis, and oxidative stress in brain tissue may develop in CTBI. These damages can be corrected with CBD treatment.

Article Details

The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects

Authors:

Adem Milletsever | Abdurrahman Gülal | Halil Aşçı

Publisher:

Süleyman Demirel University

Main Topics:

Brain and Nerve Surgery (Neurosurgery) | Thoracic Surgery | Medical Pharmacology | Chest Diseases

Journal:

Medical Journal of Süleyman Demirel University Vol.31 Issue 4, pp.332-338

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001335528

pISSN:

1300-7416

Blunt chest trauma

brain

cannabidiol

apoptosis

malondialdehyde

Issues

Article Details

The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects

Authors: Adem Milletsever | Abdurrahman Gülal | Halil Aşçı

Publisher: Süleyman Demirel University

Main Topics: Brain and Nerve Surgery (Neurosurgery) | Thoracic Surgery | Medical Pharmacology | Chest Diseases

Journal: Medical Journal of Süleyman Demirel University Vol.31 Issue 4, pp.332-338

Document Type: Article

Publication Date: 12/2024

Document Language: English

Document ID (Org No.): 2001335528

pISSN: 1300-7416

Blunt chest trauma

brain

cannabidiol

apoptosis

malondialdehyde

Issues

Authors:

Adem Milletsever | Abdurrahman Gülal | Halil Aşçı

Publisher:

Süleyman Demirel University

Main Topics:

Brain and Nerve Surgery (Neurosurgery) | Thoracic Surgery | Medical Pharmacology | Chest Diseases

Journal:

Medical Journal of Süleyman Demirel University Vol.31 Issue 4, pp.332-338

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001335528

pISSN:

1300-7416