Evaluation of Serum RANTES as a Biomarker in the Diagnosis of Early-Onset Neonatal Infections

Abd-Elsamea , Mahmoud Mohammed; El-Dousoky , Azza I.; Abd El-Rahman , Hadeel M.; Mohammad , Randa Hussiny

Article Details

Evaluation of Serum RANTES as a Biomarker in the Diagnosis of Early-Onset Neonatal Infections

Authors:

Abd-Elsamea , Mahmoud Mohammed | El-Dousoky , Azza I. | Abd El-Rahman , Hadeel M. | Mohammad , Randa Hussiny

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1609-1613

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

230417

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: Globally, sepsis is still one of the major causes of morbidity and mortality in neonates, despite recent advances in health care units.Objective: To assess the accuracy of serum chemokine RANTES as a biomarker for early-onset neonatal infection as early diagnosis and to assess its relationship with gestational age, birth weight, sex, mode of delivery, and value of some hematological and biochemical parameters facilitating early good treatment.Patients and Methods: This case-control study was carried out on neonates with early-onset neonatal infections that were admitted to the Neonatal Intensive Care Unit of Zagazig General Hospital. This study included 45 matched age and sex neonates divided into three groups.Results: Significantly higher levels of RANTES were found in neonates with EONS compared with non-infected cases. RANTES levels were significantly higher in infected term &preterm neonates compared to healthy controls. Infected full-term neonates had higher RANTES levels than in infected preterm neonates without a statistically significant difference. A positive correlation between serum RANTES concentration and CRP value was found in both infected neonates groups. On the other hand, no correlation between RANTES and the number of white blood cells, platelets, or hemoglobin was noted.Conclusion: The significant increase of serum RANTES concentration in early-onset infections in neonates, regardless of their gestational age, birth weight, and Apgar score, not only proves the presence of an active immunological process but also may be a useful biomarker for diagnosis of early-onset severe neonatal infections.

Article Details

Evaluation of Serum RANTES as a Biomarker in the Diagnosis of Early-Onset Neonatal Infections

Authors:

Abd-Elsamea , Mahmoud Mohammed | El-Dousoky , Azza I. | Abd El-Rahman , Hadeel M. | Mohammad , Randa Hussiny

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1609-1613

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

230417

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

NEONATAL DISEASES

INFECTION

SEPTICAEMIA

CRITICAL CARE

NEWBORNS

EGYPT

RANTES

Biomarker

Early

Onset Neonatal Infections

Issues

Article Details

Authors: Abd-Elsamea , Mahmoud Mohammed | El-Dousoky , Azza I. | Abd El-Rahman , Hadeel M. | Mohammad , Randa Hussiny

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1609-1613

Document Type: Article

Publication Date: 10/2020

Document Language: English

Document ID (Org No.): 230417

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Abd-Elsamea , Mahmoud Mohammed | El-Dousoky , Azza I. | Abd El-Rahman , Hadeel M. | Mohammad , Randa Hussiny

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1609-1613

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

230417

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002