Methyl-substituted 2-aminothiazole--based cobalt(II) and silver(I)   complexes: synthesis, X-ray structures, and biological activities

Ezzat KHAN; Tufail AHMAD; Zarif GUL; Farhat ULLAH; Muhammad Nawaz TAHIR; Awal NOOR

Article Details

Methyl-substituted 2-aminothiazole--based cobalt(II) and silver(I) complexes: synthesis, X-ray structures, and biological activities

Authors:

Ezzat KHAN | Tufail AHMAD | Zarif GUL | Farhat ULLAH | Muhammad Nawaz TAHIR | Awal NOOR

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2019 Vol.43 Issue 3, pp.857-868

Document Type:

Article

Publication Date:

5/2019

Document Language:

English

Document ID (Org No.):

2000725734

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

2-Aminothiazole derivatives bear three nucleophilic centers, i.e. endocyclic   N, exocyclic NH22_{2}, and S atom in the ring system. In addition to these   centers there are ππ\pi-electrons in the ring system which can also expectedly   be involved in some sort of coordination. To the best of our knowledge the   solid state coordination chemistry of such ligands has not been fully   presented in the literature. These ligands (2-amino-4-methylthiazole and   2-amino-5-methylthiazole) were coupled with CoCl22_{2} under aerobic   conditions to form tetrahedral complexes,   bis(2-amino-4-methylthiazole)dichlorocobalt(II) (1)   and bis(2-amino-5-methylthiazole)dichlorocobalt(II) (2).   Reaction of 2-amino-5-methylthiazole with AgNO33_{3} led to an expected   two-coordinated, bis(2-amino-5-methylthiazole)silver(I) nitrate (3)   as crystalline material. In all complexes the coordination behavior of the   aminothiazole derivatives was identical, coordinating to the metal center   through endocyclic N atom. The structures of these complexes were confirmed   by single-crystal X-ray analysis. Compounds (1-3) were screened   for their antimicrobial potency against gram-negative  (E. sakazkii, E. coli, K. pneumoniae) and a   gram-positive  bacteria (S. aurus). Additionally, their role as enzyme inhibitors   (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and their free   radical scavenging ability (2,2-Diphenyl-1-picrylhydrazyl, DPPH, and   2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid, ABTS) were studied.   These ligands bear additional nucleophilic centers (S and NH2)2)_{2}) and can   be involved in secondary interactions as confirmed by their solid-state   structures. These interactions make the molecules biologically important and   thus play a pivotal role in establishing the supramolecular network. We   report here the coordination chemistry and selected biological applications   of complexes 1-3.

Article Details

Methyl-substituted 2-aminothiazole--based cobalt(II) and silver(I) complexes: synthesis, X-ray structures, and biological activities

Authors: Ezzat KHAN | Tufail AHMAD | Zarif GUL | Farhat ULLAH | Muhammad Nawaz TAHIR | Awal NOOR

Publisher: TUBITAK

Main Topics: Applied physics

Journal: Turkish Journal of Chemistry 2019 Vol.43 Issue 3, pp.857-868

Document Type: Article

Publication Date: 5/2019

Document Language: English

Document ID (Org No.): 2000725734

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Ezzat KHAN | Tufail AHMAD | Zarif GUL | Farhat ULLAH | Muhammad Nawaz TAHIR | Awal NOOR

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2019 Vol.43 Issue 3, pp.857-868

Document Type:

Article

Publication Date:

5/2019

Document Language:

English

Document ID (Org No.):

2000725734

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527