Total oxidant and antioxidant status and paraoxonase 1 levels ofchildren with noncystic fibrosis bronchiectasis

Ahmet Hakan GEDİK; Erkan ÇAKIR; Aysel Vehapoğlu TÜRKMEN; Ömer Faruk ÖZER; Sare Betül KAYGUSUZ

doi:https://doi.org/10.3906/sag-1503-99

Article Details

Total oxidant and antioxidant status and paraoxonase 1 levels ofchildren with noncystic fibrosis bronchiectasis

Authors:

Ahmet Hakan GEDİK | Erkan ÇAKIR | Aysel Vehapoğlu TÜRKMEN | Ömer Faruk ÖZER | Sare Betül KAYGUSUZ

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.1-8

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000749632

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1503-99

Abstract:

 

Background/aim: To evaluate total oxidant status  TOS , total antioxidant capacity  TAC , and paraoxonase 1  PON1  levels in children with noncystic fibrosis  CF  bronchiectasis  BE , and to compare these levels with those of healthy controls. The study parameters were also evaluated according to some demographic, anthropometric, and clinical characteristics, as well as lung functions. Materials and methods: Enrolled in the study were 118 children with non-CF BE and 68 healthy controls. Serum TOS, TAC, and PON1 levels were determined. Lung function tests were performed by spirometry. Results: Serum TOS was higher in the patients [median 9.54  IQR 25-75 = 7.05-13.30  µmol H2O2 Eq/L] than in the healthy subjects [6.64  5.45-9.53  µmol H2O2 Eq/L]  P < 0.001 . TAC was higher in patients with non-CF BE [1.07  1.0-1.07  mmol Trolox Eq/L] than in the healthy controls [0.87  0.77-0.98  mmol Trolox Eq/L]  P < 0.001 . In addition, serum PON1 levels were significantly higher in the patients [106.5  42.5-154.2  U/L] than in the controls [47.7  27.5-82.1  U/L]  P < 0.001 . The patients with low FEV1 had decreased TAC when compared to those who had normal FEV1 in non-CF BE. Conclusion: The present study demonstrated that compared with the control group the children with non-CF BE had elevated oxidative status, antioxidant defenses parameters, and PON1 values.

Article Details

Total oxidant and antioxidant status and paraoxonase 1 levels ofchildren with noncystic fibrosis bronchiectasis

Authors: Ahmet Hakan GEDİK | Erkan ÇAKIR | Aysel Vehapoğlu TÜRKMEN | Ömer Faruk ÖZER | Sare Betül KAYGUSUZ

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.1-8

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 2000749632

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1503-99

Issues

Authors:

Ahmet Hakan GEDİK | Erkan ÇAKIR | Aysel Vehapoğlu TÜRKMEN | Ömer Faruk ÖZER | Sare Betül KAYGUSUZ

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.1-8

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000749632

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1503-99