Ovarian stimulation induces high expression of interleukin-1ß and disrupts the histological features of the fallopian tube

Mahmoud MOUSSA; Sameh Mohamed FAROUK

Article Details

Ovarian stimulation induces high expression of interleukin-1ß and disrupts the histological features of the fallopian tube

Authors:

Mahmoud MOUSSA | Sameh Mohamed FAROUK

Publisher:

TUBITAK

Journal:

Turkish Journal of Veterinary and Animal Sciences 2019 Vol.43 Issue 2, pp.186-196

Document Type:

Article

Publication Date:

3/2019

Document Language:

Turkish

Document ID (Org No.):

2000764330

Frequency:

Bimonthly

eISSN:

1303-6181

pISSN:

1300-0128

Abstract:

 

The objective of this study was to investigate whether there is an association between ovarian stimulation and interrupted gamete interaction in the rat fallopian tube in vivo. We evaluated the protein expression of interleukin-1ß (IL-1ß) via immunohistochemistry and assessed the key histological features of the ovaries, fallopian tubes, and uteri of the rats following treatment with mild (15 IU) and high (30 IU) doses of gonadotropins compared to an unstimulated control group. The serum concentration of estradiol was also determined by immunoassay. The results revealed that high levels of circulating estrogen were associated with higher expression of the IL-1ß protein in the ovaries and fallopian tubes of highly stimulated rats than in those of the mildly stimulated and unstimulated control groups. In contrast, endometrial IL-1ß immunoexpression was not affected by ovarian stimulation. The histological features of the fallopian tubes were also dramatically altered upon ovarian stimulation, reducing the efficiency of the fallopian tube. In conclusion, the resulting high circulating estrogen level disrupts the histological features of the fallopian tubes and can lead to higher expression of IL-1ß, thus negatively affecting gamete interactions in vivo. These results provide useful information regarding the lower fertilization rate observed following ovarian stimulation.

Article Details

Ovarian stimulation induces high expression of interleukin-1ß and disrupts the histological features of the fallopian tube

Authors: Mahmoud MOUSSA | Sameh Mohamed FAROUK

Publisher: TUBITAK

Journal: Turkish Journal of Veterinary and Animal Sciences 2019 Vol.43 Issue 2, pp.186-196

Document Type: Article

Publication Date: 3/2019

Document Language: Turkish

Document ID (Org No.): 2000764330

Frequency: Bimonthly

eISSN: 1303-6181

pISSN: 1300-0128

Issues

Authors:

Mahmoud MOUSSA | Sameh Mohamed FAROUK

Publisher:

TUBITAK

Journal:

Turkish Journal of Veterinary and Animal Sciences 2019 Vol.43 Issue 2, pp.186-196

Document Type:

Article

Publication Date:

3/2019

Document Language:

Turkish

Document ID (Org No.):

2000764330

Frequency:

Bimonthly

eISSN:

1303-6181

pISSN:

1300-0128