Positive correlation of galanin with insulin resistance and triglyceride levels in obese  children

Sezer ACAR; Ahu PAKETÇİ; Tuncay KÜME; Korcan DEMİR; Özlem Gürsoy ÇALAN; Ece BÖBER; Ayhan ABACI

Article Details

Positive correlation of galanin with insulin resistance and triglyceride levels in obese children

Authors:

Sezer ACAR | Ahu PAKETÇİ | Tuncay KÜME | Korcan DEMİR | Özlem Gürsoy ÇALAN | Ece BÖBER | Ayhan ABACI

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.560-568

Document Type:

Article

Publication Date:

5/2018

Document Language:

Turkish

Document ID (Org No.):

2000750724

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Abstract:

 

Background/aim: Galanin is a neuropeptide that is shown to be involved in the regulation of food intake and glucose homeostasis. The  objective of this study was to evaluate the relation of serum galanin levels with anthropometric and metabolic parameters in obese and  healthy children.  Material and methods: The cross-sectional study consisted of 38 obese children (mean age: 11.9 ± 3.0 years) and 30 healthy children  (mean age: 11.4 ± 2.0 years). Clinical and biochemical parameters [glucose, insulin, homeostasis model assessment-insulin resistance  (HOMA-IR), lipids, galanin, and leptin levels] were assessed.  Results: Serum galanin and leptin levels were significantly higher in obese children. In obese children, galanin levels were positively  correlated with fasting glucose (r = 0.398, p = 0.013), insulin (r = 0.383, p = 0.018), HOMA-IR (r = 0.375, p = 0.020), and triglycerides  (r = 0.391, p=0.015). Multivariate backward regression analysis revealed that galanin levels were significantly associated with fasting  glucose, insulin, HOMA-IR, and triglyceride, which explained 42.0% of the variance (r2 = 0.483, P < 0.001).  Conclusions: Serum galanin levels were significantly higher in obese children than healthy controls and positively correlated with  insulin resistance and triglycerides in obese children. This study suggests that galanin is associated with glucose homeostasis and lipid  metabolism in childhood obesity.

Article Details

Positive correlation of galanin with insulin resistance and triglyceride levels in obese children

Authors: Sezer ACAR | Ahu PAKETÇİ | Tuncay KÜME | Korcan DEMİR | Özlem Gürsoy ÇALAN | Ece BÖBER | Ayhan ABACI

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.560-568

Document Type: Article

Publication Date: 5/2018

Document Language: Turkish

Document ID (Org No.): 2000750724

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Issues

Authors:

Sezer ACAR | Ahu PAKETÇİ | Tuncay KÜME | Korcan DEMİR | Özlem Gürsoy ÇALAN | Ece BÖBER | Ayhan ABACI

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.560-568

Document Type:

Article

Publication Date:

5/2018

Document Language:

Turkish

Document ID (Org No.):

2000750724

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144