Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Yusuf KARAGÖZOĞLU; Akif Evren PARLAK; Naci Ömer ALAYUNT; Semra TÜRKOĞLU; İsil YİLDİRİM; Mustafa KARATEPE

doi:https://doi.org/10.37212/jcnos.579145

Article Details

Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Authors:

Yusuf KARAGÖZOĞLU | Akif Evren PARLAK | Naci Ömer ALAYUNT | Semra TÜRKOĞLU | İsil YİLDİRİM | Mustafa KARATEPE

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Journal of Cellular Neuroscience and Oxidative Stress 2019 Vol.11 Issue 1, pp.797-804

Document Type:

Article

Publication Date:

6/2019

Document Language:

English

Document ID (Org No.):

2000708803

Frequency:

Tri-annual

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.579145

Abstract:

 


In this study, effects of hydroxyurea derivatives 1, 3, 4 - thiadiazole and schiff base compounds on some element levels and antioxidant enzyme activities in rat liver and on antioxidant enzyme levels that are parameters of oxidative stress were investigated. For this purpose, iron (Fe), zinc (Zn) and copper (Cu) concentrations were analyzed by using atomic absorption spectroscopy superoxide dismutase (SOD) and catalase (CAT) activities were measured by using a UV spectrophotometer. Fe, Zn and Cu concentrations in the liver of rats treated with these compounds were compared with levels of SOD and CAT statistically. As a result, the increase in the antioxidant activities of SOD and CAT metalloenzymes together with decrease in levels of Cu, Zn and Fe elements observed may suggest that the elements be bound to these enzymes. 

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Article Details

Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Authors: Yusuf KARAGÖZOĞLU | Akif Evren PARLAK | Naci Ömer ALAYUNT | Semra TÜRKOĞLU | İsil YİLDİRİM | Mustafa KARATEPE

Publisher: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal: Journal of Cellular Neuroscience and Oxidative Stress 2019 Vol.11 Issue 1, pp.797-804

Document Type: Article

Publication Date: 6/2019

Document Language: English

Document ID (Org No.): 2000708803

Frequency: Tri-annual

eISSN: 2149-7222

DOI: https://doi.org/10.37212/jcnos.579145

Issues

Authors:

Yusuf KARAGÖZOĞLU | Akif Evren PARLAK | Naci Ömer ALAYUNT | Semra TÜRKOĞLU | İsil YİLDİRİM | Mustafa KARATEPE

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Journal of Cellular Neuroscience and Oxidative Stress 2019 Vol.11 Issue 1, pp.797-804

Document Type:

Article

Publication Date:

6/2019

Document Language:

English

Document ID (Org No.):

2000708803

Frequency:

Tri-annual

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.579145