Emerging roles of ADAMTS metalloproteinases in regenerativemedicine and restorative biology

FERAH ARMUTCU; KADİR DEMİRCAN

Article Details

Emerging roles of ADAMTS metalloproteinases in regenerativemedicine and restorative biology

Authors:

FERAH ARMUTCU | KADİR DEMİRCAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2016 Vol.40 Issue 2, pp.308-315

Document Type:

Article

Publication Date:

3/2016

Document Language:

Turkish

Document ID (Org No.):

2000811705

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

Abstract:

 

ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteinases degrade proteoglycans and thereby have the potential to alter tissue architecture and regulate cellular function. Recent studies about the roles of these enzymes have produced new perspectives for the molecular mechanisms behind regenerative biology with clinical potential to generate therapeutic targets to resolve tissue injury. ADAMTS enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as inflammation and fibrosis. Increasing evidence indicates that they may be of key significance in the physiological and pathological central nervous system. In this review, we summarize what is currently known about the roles of ADAMTS proteins in tissue repair and regeneration as well as in the pathogenesis of other important biological processes and diseases including arthritis, atherosclerosis, and cancer.

Article Details

Emerging roles of ADAMTS metalloproteinases in regenerativemedicine and restorative biology

Authors: FERAH ARMUTCU | KADİR DEMİRCAN

Publisher: TUBITAK

Journal: Turkish Journal of Biology 2016 Vol.40 Issue 2, pp.308-315

Document Type: Article

Publication Date: 3/2016

Document Language: Turkish

Document ID (Org No.): 2000811705

Frequency: Bimonthly

eISSN: 1303-6092

pISSN: 1300-0152

Issues

Authors:

FERAH ARMUTCU | KADİR DEMİRCAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2016 Vol.40 Issue 2, pp.308-315

Document Type:

Article

Publication Date:

3/2016

Document Language:

Turkish

Document ID (Org No.):

2000811705

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152