Gabapentin in Cattle: A Pharmacology Snapshot

Charbel Fadel; Irene Sartini; Mario Giorgi; Mario Giorgi

doi:10.3844/ajavsp.2022.187.197

Article Details

Gabapentin in Cattle: A Pharmacology Snapshot

Authors:

Charbel Fadel | Irene Sartini | Mario Giorgi | Mario Giorgi

Publisher:

Science Publications

Journal:

American Journal of Animal and Veterinary Sciences Vol.17 Issue 3, pp.187-197

Document Type:

Article

Publication Date:

7/2022

Document Language:

English

Document ID (Org No.):

2001396681

pISSN:

1557-4563

DOI:

10.3844/ajavsp.2022.187.197

Keywords:

Abstract:

 Gabapentin (GBP) is an antiepileptic and analgesic drug that is derived from gamma-aminobutyric acid. It is used as an analgesic in multi-modal pain management, as well as an anticonvulsant and anxiolytic, off-label in animals. Particularly, oral GBP prescriptions for cattle are becoming increasingly popular. Since its introduction into cattle farm practices, several types of research on GBP in cattle have been published, covering pharmacokinetics and safety studies. Other studies concerning cattle dehorning and lameness have found synergism when GBP and meloxicam are co-administered. Because of the significant therapeutic effect of these medications when used together, practical veterinarians might be able to execute other surgical procedures on cattle without causing pain to the animals. This is important because pain management and the prevention of animal suffering are critical components of the animal well-being approach in veterinary medicine. Oral doses between 10 and 20 mg/kg were safe, and effective in dehorning and lameness, in combination with MEL. Such dose is preferable to be administered 8 h before any procedure, as part of the preemptive therapy. This review focuses on the clinical applications and therapeutic effects of GBP in cattle, both for farming practices and surgical interventions.

Article Details

Gabapentin in Cattle: A Pharmacology Snapshot

Authors:

Charbel Fadel | Irene Sartini | Mario Giorgi | Mario Giorgi

Publisher:

Science Publications

Journal:

American Journal of Animal and Veterinary Sciences Vol.17 Issue 3, pp.187-197

Document Type:

Article

Publication Date:

7/2022

Document Language:

English

Document ID (Org No.):

2001396681

pISSN:

1557-4563

DOI:

10.3844/ajavsp.2022.187.197

Cattle

Gabapentin

Analgesia

Pharmacodynamics

Pharmacokinetics

Pain Management

Issues

Article Details

Gabapentin in Cattle: A Pharmacology Snapshot

Authors: Charbel Fadel | Irene Sartini | Mario Giorgi | Mario Giorgi

Publisher: Science Publications

Journal: American Journal of Animal and Veterinary Sciences Vol.17 Issue 3, pp.187-197

Document Type: Article

Publication Date: 7/2022

Document Language: English

Document ID (Org No.): 2001396681

pISSN: 1557-4563

DOI: 10.3844/ajavsp.2022.187.197

Cattle

Gabapentin

Analgesia

Pharmacodynamics

Pharmacokinetics

Pain Management

Issues

Authors:

Charbel Fadel | Irene Sartini | Mario Giorgi | Mario Giorgi

Publisher:

Science Publications

Journal:

American Journal of Animal and Veterinary Sciences Vol.17 Issue 3, pp.187-197

Document Type:

Article

Publication Date:

7/2022

Document Language:

English

Document ID (Org No.):

2001396681

pISSN:

1557-4563

DOI:

10.3844/ajavsp.2022.187.197