Protective effects of lupeol on acute exercise-related  oxidative stress in male rats

Emrah Özdemir; Hakkı Çoknaz; Sıla Özlem Sener; Ufuk Özgen; Ali Gök

Article Details

Protective effects of lupeol on acute exercise-related oxidative stress in male rats

Authors:

Emrah Özdemir | Hakkı Çoknaz | Sıla Özlem Sener | Ufuk Özgen | Ali Gök

Publisher:

Marmara University

Main Topics:

Pharmaceutical Sciences

Journal:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.2008-2016

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001334774

pISSN:

2630-6344

Keywords:

Abstract:

 The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats. Rats were randomly selected and divided into four groups n6group: Control, exercise, lupeol and exerciselupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase SOD, catalase CAT, malondialdehyde MDA, glutathione GSH, coenzyme Q10 CoQ10 and α-lipoic acid ALA and oxidative stress levels in serum samples were measured. As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed to oxidative stress inhibits free radicals formed by stress. In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage.

 The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats. Rats were randomly selected and divided into four groups n6group: Control, exercise, lupeol and exerciselupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase SOD, catalase CAT, malondialdehyde MDA, glutathione GSH, coenzyme Q10 CoQ10 and α-lipoic acid ALA and oxidative stress levels in serum samples were measured. As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed to oxidative stress inhibits free radicals formed by stress. In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage.

 The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats. Rats were randomly selected and divided into four groups n6group: Control, exercise, lupeol and exerciselupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase SOD, catalase CAT, malondialdehyde MDA, glutathione GSH, coenzyme Q10 CoQ10 and α-lipoic acid ALA and oxidative stress levels in serum samples were measured. As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed to oxidative stress inhibits free radicals formed by stress. In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage.

 The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats. Rats were randomly selected and divided into four groups n6group: Control, exercise, lupeol and exerciselupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase SOD, catalase CAT, malondialdehyde MDA, glutathione GSH, coenzyme Q10 CoQ10 and α-lipoic acid ALA and oxidative stress levels in serum samples were measured. As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed to oxidative stress inhibits free radicals formed by stress. In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage.

Article Details

Protective effects of lupeol on acute exercise-related oxidative stress in male rats

Authors:

Emrah Özdemir | Hakkı Çoknaz | Sıla Özlem Sener | Ufuk Özgen | Ali Gök

Publisher:

Marmara University

Main Topics:

Pharmaceutical Sciences

Journal:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.2008-2016

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001334774

pISSN:

2630-6344

Antioxidant

exercise

free radical

lupeol

oxidative stress

Issues

Article Details

Protective effects of lupeol on acute exercise-related oxidative stress in male rats

Authors: Emrah Özdemir | Hakkı Çoknaz | Sıla Özlem Sener | Ufuk Özgen | Ali Gök

Publisher: Marmara University

Main Topics: Pharmaceutical Sciences

Journal: Journal of Research in Pharmacy Vol.28 Issue 6, pp.2008-2016

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001334774

pISSN: 2630-6344

Antioxidant

exercise

free radical

lupeol

oxidative stress

Issues

Authors:

Emrah Özdemir | Hakkı Çoknaz | Sıla Özlem Sener | Ufuk Özgen | Ali Gök

Publisher:

Marmara University

Main Topics:

Pharmaceutical Sciences

Journal:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.2008-2016

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001334774

pISSN:

2630-6344