THE GREEN APPROACH FOR THE SYNTHESIS OF SOME HYDROQUINOLINE DERIVATIVES COMPOUND VIA HANTZSCH REACTION

Layla Ahmed Othman

Article Details

THE GREEN APPROACH FOR THE SYNTHESIS OF SOME HYDROQUINOLINE DERIVATIVES COMPOUND VIA HANTZSCH REACTION

Authors:

Layla Ahmed Othman

Publisher:

University of Zakho, Iraq

Journal:

Science Journal of University of Zakho Vol.12 Issue 4, pp.427-435

Document Type:

Article

Publication Date:

10/2024

Document Language:

English

Document ID (Org No.):

2001934996

pISSN:

2663-6298

Keywords:

Abstract:

 Since that hydroquinoline and acridine compounds serve as the fundamental building blocks for the synthesis of many different pharmaceuticals, they are among the most significant classes of chemical compounds that attract the interest of numerous researchers and pharmacologists. Therefore, in this research, The Hantzch reaction was used to prepare these types hydroquinoline and acridine  derivatives of compounds, through the reaction  of a number substituted benzaldehyde with demidone and  α-β diketone substitutes by refluxed with sodium acetate in the presence of iodine and a 1-sulfo-4-(3-(Ferricoxide-Silicondioxide nanopowdertrioxisilyl)propyl) piperazinum-1,4-diphosphate as a catalyst to form 7,7- dimethyl -4,6,7,8-tetrahydroquinoline derivatives which is represented by compounds (1-12) or in the same way by react  benzaldehyde substitutes react with demidone and 4-isopropyl cyclohexanone 1-one to form acridin derivatives  represented by compounds (13 -17). All product compound are characterized using 1H-NMR spectra and the results confirmed the structures.

Article Details

THE GREEN APPROACH FOR THE SYNTHESIS OF SOME HYDROQUINOLINE DERIVATIVES COMPOUND VIA HANTZSCH REACTION

Authors:

Layla Ahmed Othman

Publisher:

University of Zakho, Iraq

Journal:

Science Journal of University of Zakho Vol.12 Issue 4, pp.427-435

Document Type:

Article

Publication Date:

10/2024

Document Language:

English

Document ID (Org No.):

2001934996

pISSN:

2663-6298

Organic Synthesis

Nanocatalyst

Hantzsch Reaction

Dimedone

Quinoline

Quinoline derivatives

Issues

Article Details

THE GREEN APPROACH FOR THE SYNTHESIS OF SOME HYDROQUINOLINE DERIVATIVES COMPOUND VIA HANTZSCH REACTION

Authors: Layla Ahmed Othman

Publisher: University of Zakho, Iraq

Journal: Science Journal of University of Zakho Vol.12 Issue 4, pp.427-435

Document Type: Article

Publication Date: 10/2024

Document Language: English

Document ID (Org No.): 2001934996

pISSN: 2663-6298

Organic Synthesis

Nanocatalyst

Hantzsch Reaction

Dimedone

Quinoline

Quinoline derivatives

Issues

Authors:

Layla Ahmed Othman

Publisher:

University of Zakho, Iraq

Journal:

Science Journal of University of Zakho Vol.12 Issue 4, pp.427-435

Document Type:

Article

Publication Date:

10/2024

Document Language:

English

Document ID (Org No.):

2001934996

pISSN:

2663-6298