Quantification of alpha-lipoic acid in pharmaceutical samples using Pd(II) catalyzed ligand substitution reaction in SLS micellar medium

N.A.

Article Details

Quantification of alpha-lipoic acid in pharmaceutical samples using Pd(II) catalyzed ligand substitution reaction in SLS micellar medium

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Chemistry

Journal:

Journal of Research in Pharmacy Vol.28 Issue 2, pp.447-457

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346199

pISSN:

2630-6344

Keywords:

Abstract:

 A novel, repeatable, and swift kinetic approach for determining alpha-lipoic acid ALA in sodium lauryl sulfate SLS micellar medium has been presented, and it has been connected to ALA determination in drug formulations. The approach is based on ALA inhibitory property. ALA containing two sulfur atoms forms a chelate with Pd2, lowering the effective PdII, and ultimately, the Pd2 catalyzed cyanide substitution rate from RuCN64- by pyrazine Pz. Fixed times of 5 and 10 minutes were chosen under optimal reaction conditions with Pyrazine  3.0  10-4 mole L-1, pH  4.0  0.02, Temp  318  0.2 K, I  0.1 mole L-1 NaClO4, RuCN64-  2.75  10-5 mole L-1, Pd2  6.0  10-5 mole L-1, and SLS  8.5  10-3 mole L-1 to calculate the absorbance at 370 nm associated with the final substitution product RuCN5 Pz3-. ALAs inhibiting influence on the Pd2 catalyzed cyanide substitution with pyrazine from RuCN64-, has been represented by a modified mechanistic approach. The concentration of ALA in various water specimens can be measured at the micro-level down to 1.25  10-6 mole L-1 using the established kinetic spectrophotometric approach. The suggested method is highly reproducible and has been effectively applied to accurately quantify the ALA in pharmaceutical samples. Even as much as 1000 with ALA, typical additives used in medications do not significantly hinder the determination of ALA.

 A novel, repeatable, and swift kinetic approach for determining alpha-lipoic acid ALA in sodium lauryl sulfate SLS micellar medium has been presented, and it has been connected to ALA determination in drug formulations. The approach is based on ALA inhibitory property. ALA containing two sulfur atoms forms a chelate with Pd2, lowering the effective PdII, and ultimately, the Pd2 catalyzed cyanide substitution rate from RuCN64- by pyrazine Pz. Fixed times of 5 and 10 minutes were chosen under optimal reaction conditions with Pyrazine  3.0  10-4 mole L-1, pH  4.0  0.02, Temp  318  0.2 K, I  0.1 mole L-1 NaClO4, RuCN64-  2.75  10-5 mole L-1, Pd2  6.0  10-5 mole L-1, and SLS  8.5  10-3 mole L-1 to calculate the absorbance at 370 nm associated with the final substitution product RuCN5 Pz3-. ALAs inhibiting influence on the Pd2 catalyzed cyanide substitution with pyrazine from RuCN64-, has been represented by a modified mechanistic approach. The concentration of ALA in various water specimens can be measured at the micro-level down to 1.25  10-6 mole L-1 using the established kinetic spectrophotometric approach. The suggested method is highly reproducible and has been effectively applied to accurately quantify the ALA in pharmaceutical samples. Even as much as 1000 with ALA, typical additives used in medications do not significantly hinder the determination of ALA.

 A novel, repeatable, and swift kinetic approach for determining alpha-lipoic acid ALA in sodium lauryl sulfate SLS micellar medium has been presented, and it has been connected to ALA determination in drug formulations. The approach is based on ALA inhibitory property. ALA containing two sulfur atoms forms a chelate with Pd2, lowering the effective PdII, and ultimately, the Pd2 catalyzed cyanide substitution rate from RuCN64- by pyrazine Pz. Fixed times of 5 and 10 minutes were chosen under optimal reaction conditions with Pyrazine  3.0  10-4 mole L-1, pH  4.0  0.02, Temp  318  0.2 K, I  0.1 mole L-1 NaClO4, RuCN64-  2.75  10-5 mole L-1, Pd2  6.0  10-5 mole L-1, and SLS  8.5  10-3 mole L-1 to calculate the absorbance at 370 nm associated with the final substitution product RuCN5 Pz3-. ALAs inhibiting influence on the Pd2 catalyzed cyanide substitution with pyrazine from RuCN64-, has been represented by a modified mechanistic approach. The concentration of ALA in various water specimens can be measured at the micro-level down to 1.25  10-6 mole L-1 using the established kinetic spectrophotometric approach. The suggested method is highly reproducible and has been effectively applied to accurately quantify the ALA in pharmaceutical samples. Even as much as 1000 with ALA, typical additives used in medications do not significantly hinder the determination of ALA.

 A novel, repeatable, and swift kinetic approach for determining alpha-lipoic acid ALA in sodium lauryl sulfate SLS micellar medium has been presented, and it has been connected to ALA determination in drug formulations. The approach is based on ALA inhibitory property. ALA containing two sulfur atoms forms a chelate with Pd2, lowering the effective PdII, and ultimately, the Pd2 catalyzed cyanide substitution rate from RuCN64- by pyrazine Pz. Fixed times of 5 and 10 minutes were chosen under optimal reaction conditions with Pyrazine  3.0  10-4 mole L-1, pH  4.0  0.02, Temp  318  0.2 K, I  0.1 mole L-1 NaClO4, RuCN64-  2.75  10-5 mole L-1, Pd2  6.0  10-5 mole L-1, and SLS  8.5  10-3 mole L-1 to calculate the absorbance at 370 nm associated with the final substitution product RuCN5 Pz3-. ALAs inhibiting influence on the Pd2 catalyzed cyanide substitution with pyrazine from RuCN64-, has been represented by a modified mechanistic approach. The concentration of ALA in various water specimens can be measured at the micro-level down to 1.25  10-6 mole L-1 using the established kinetic spectrophotometric approach. The suggested method is highly reproducible and has been effectively applied to accurately quantify the ALA in pharmaceutical samples. Even as much as 1000 with ALA, typical additives used in medications do not significantly hinder the determination of ALA.

Article Details

Quantification of alpha-lipoic acid in pharmaceutical samples using Pd(II) catalyzed ligand substitution reaction in SLS micellar medium

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Chemistry

Journal:

Journal of Research in Pharmacy Vol.28 Issue 2, pp.447-457

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346199

pISSN:

2630-6344

Inhibitory effect

Alpha-lipoic acid

Surfactant medium

Pharmaceutical preparations

Pd(II); Excipients

Issues

Article Details

Quantification of alpha-lipoic acid in pharmaceutical samples using Pd(II) catalyzed ligand substitution reaction in SLS micellar medium

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmaceutical Chemistry

Journal: Journal of Research in Pharmacy Vol.28 Issue 2, pp.447-457

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001346199

pISSN: 2630-6344

Inhibitory effect

Alpha-lipoic acid

Surfactant medium

Pharmaceutical preparations

Pd(II); Excipients

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Chemistry

Journal:

Journal of Research in Pharmacy Vol.28 Issue 2, pp.447-457

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346199

pISSN:

2630-6344