Isorhamnetin as a promising natural bioactive flavonoid:  in vitro assessment of its antifungal property

Tuba Unver

Article Details

Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property

Authors:

Tuba Unver

Publisher:

Gültekin ÖZDEMİR

Main Topics:

Medicinal and Aromatic Plants

Journal:

International Journal of Agriculture Environment and Food Sciences Vol.8 Issue 1, pp.54-61

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001313899

pISSN:

2618-5946

Keywords:

Abstract:

 Isorhamnetin 3-methylquercetin is an important flavonoid produced as a secondary metabolite from medicinal and aromatic plants due to its pharmacological and therapeutic properties. Thus far, the anticancer, antiallergic, antiinflammatory, antioxidant, antiviral, and antimicrobial properties of isorhamnetin have been evaluated in indirect studies conducted with isorhamnetin found in plant extracts or essential oils or direct studies performed with pure isorhamnetin. However, this is the first study in the literature on the antifungal activity of 97 pure isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis using two assays including agar dilution and broth microdilution methods. This study showed that isorhamnetin has a significant inhibitory effect against all Candida species used. The minimum inhibitory concentration MIC value of isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis was 1.875 mgmL, the same for all yeast strains. These results have opened a new horizon regarding the usability of isorhamnetin as a pharmacological therapeutic antifungal agent.

 Isorhamnetin 3-methylquercetin is an important flavonoid produced as a secondary metabolite from medicinal and aromatic plants due to its pharmacological and therapeutic properties. Thus far, the anticancer, antiallergic, antiinflammatory, antioxidant, antiviral, and antimicrobial properties of isorhamnetin have been evaluated in indirect studies conducted with isorhamnetin found in plant extracts or essential oils or direct studies performed with pure isorhamnetin. However, this is the first study in the literature on the antifungal activity of 97 pure isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis using two assays including agar dilution and broth microdilution methods. This study showed that isorhamnetin has a significant inhibitory effect against all Candida species used. The minimum inhibitory concentration MIC value of isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis was 1.875 mgmL, the same for all yeast strains. These results have opened a new horizon regarding the usability of isorhamnetin as a pharmacological therapeutic antifungal agent.

 Isorhamnetin 3-methylquercetin is an important flavonoid produced as a secondary metabolite from medicinal and aromatic plants due to its pharmacological and therapeutic properties. Thus far, the anticancer, antiallergic, antiinflammatory, antioxidant, antiviral, and antimicrobial properties of isorhamnetin have been evaluated in indirect studies conducted with isorhamnetin found in plant extracts or essential oils or direct studies performed with pure isorhamnetin. However, this is the first study in the literature on the antifungal activity of 97 pure isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis using two assays including agar dilution and broth microdilution methods. This study showed that isorhamnetin has a significant inhibitory effect against all Candida species used. The minimum inhibitory concentration MIC value of isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis was 1.875 mgmL, the same for all yeast strains. These results have opened a new horizon regarding the usability of isorhamnetin as a pharmacological therapeutic antifungal agent.

 Isorhamnetin 3-methylquercetin is an important flavonoid produced as a secondary metabolite from medicinal and aromatic plants due to its pharmacological and therapeutic properties. Thus far, the anticancer, antiallergic, antiinflammatory, antioxidant, antiviral, and antimicrobial properties of isorhamnetin have been evaluated in indirect studies conducted with isorhamnetin found in plant extracts or essential oils or direct studies performed with pure isorhamnetin. However, this is the first study in the literature on the antifungal activity of 97 pure isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis using two assays including agar dilution and broth microdilution methods. This study showed that isorhamnetin has a significant inhibitory effect against all Candida species used. The minimum inhibitory concentration MIC value of isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis was 1.875 mgmL, the same for all yeast strains. These results have opened a new horizon regarding the usability of isorhamnetin as a pharmacological therapeutic antifungal agent.

Article Details

Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property

Authors:

Tuba Unver

Publisher:

Gültekin ÖZDEMİR

Main Topics:

Medicinal and Aromatic Plants

Journal:

International Journal of Agriculture Environment and Food Sciences Vol.8 Issue 1, pp.54-61

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001313899

pISSN:

2618-5946

Isorhamnetin

Flavonoids

Antifungal Activity

Pharmaceutical compound

Therapy

Issues

Article Details

Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property

Authors: Tuba Unver

Publisher: Gültekin ÖZDEMİR

Main Topics: Medicinal and Aromatic Plants

Journal: International Journal of Agriculture Environment and Food Sciences Vol.8 Issue 1, pp.54-61

Document Type: Article

Publication Date: 3/2024

Document Language: English

Document ID (Org No.): 2001313899

pISSN: 2618-5946

Isorhamnetin

Flavonoids

Antifungal Activity

Pharmaceutical compound

Therapy

Issues

Authors:

Tuba Unver

Publisher:

Gültekin ÖZDEMİR

Main Topics:

Medicinal and Aromatic Plants

Journal:

International Journal of Agriculture Environment and Food Sciences Vol.8 Issue 1, pp.54-61

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001313899

pISSN:

2618-5946