Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Fatma Gökçe APAYDIN; Kaan KALTALIOĞLU; Barbaros BALABANLI; Şule COSKUN CEVHER

Article Details

Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Authors:

Fatma Gökçe APAYDIN | Kaan KALTALIOĞLU | Barbaros BALABANLI | Şule COSKUN CEVHER

Publisher:

Gazi University

Main Topics:

Applied physics

Journal:

Gazi University Journal of Science 2018 Vol.31 Issue 2, pp.399-406

Document Type:

Article

Publication Date:

5/2018

Document Language:

English

Document ID (Org No.):

2000428201

eISSN:

2147-1762

Abstract:

 


In this study, we investigated that the histopathological
changes of rat kidney and liver tissues after cisplatin administration and potential
beneficial effects of morin and hesperidin administration. Wistar rats were
randomly divided in 7 groups: control, morin (M), hesperidin (H), cisplatin
(CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H), cisplatin+morin+hesperidin
(CP+M+H). Kidney and liver tissues were collected at the end of the experiment
and were evaluated histopathological changes. Various histopathological changes
in kidney and liver tissues of cisplatin-induced group were revealed. However, pre-
and co-treatment of morin and/or hesperidin partially prevented these
hepatotoxic and nephrotoxic changes in cisplatin-induced groups.


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Article Details

Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Authors: Fatma Gökçe APAYDIN | Kaan KALTALIOĞLU | Barbaros BALABANLI | Şule COSKUN CEVHER

Publisher: Gazi University

Main Topics: Applied physics

Journal: Gazi University Journal of Science 2018 Vol.31 Issue 2, pp.399-406

Document Type: Article

Publication Date: 5/2018

Document Language: English

Document ID (Org No.): 2000428201

eISSN: 2147-1762

Issues

Authors:

Fatma Gökçe APAYDIN | Kaan KALTALIOĞLU | Barbaros BALABANLI | Şule COSKUN CEVHER

Publisher:

Gazi University

Main Topics:

Applied physics

Journal:

Gazi University Journal of Science 2018 Vol.31 Issue 2, pp.399-406

Document Type:

Article

Publication Date:

5/2018

Document Language:

English

Document ID (Org No.):

2000428201

eISSN:

2147-1762