Formulation and evaluation of fluvastatin sodium drugin-adhesive transdermal system

N.A.

Article Details

Formulation and evaluation of fluvastatin sodium drugin-adhesive transdermal system

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.24 Issue 4, pp.562-571

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347943

pISSN:

2630-6344

Keywords:

Abstract:

 Current investigation is aimed at designing a fluvastatin sodium loaded drug-in-adhesive patch DIA Patch  to overcome the problems associated with the daily oral administration of the drug. The patches were prepared by solvent casting method using acrylate emulsion polymers like covinax 525-78, mowinyl 461 and novacryl PSR32 which served as sustained release matrix polymer and adhesive. Methocel K-15M was added as a solubilizer whereas transcutol, oleic acid and isopropyl myristate were tried as permeation enhancers for the drug-in-adhesive patch. The combination of mowinyl-isopropyl myristate patch was further optimized by 32 factorial design to study the effect of two independent variables i.e. concentration of solubilizer and permeation enhancer on responses i.e. drug release, tensile strength and peel adhesion strength. The formulation was further evaluated for its lipid lowering activity and skin irritation index. The  cumulative release of drug at the end of 24 h was found to be 87.74. The formulation shows tensile strength of 12.75 kgcm2 and peel adhesion strength of 32.44 N25 mm. The Primary irritation index PII for DIA patch was found to be 0.22. The fluvastatin sodium loaded DIA patch significantly inhibits serum cholesterol and triglyceride levels as compared to oral control p0.01 in triton WR 1339 induced hyperlipidemic rat. Hence the developed transdermal patch could be acceptable for transdermal use.

 Current investigation is aimed at designing a fluvastatin sodium loaded drug-in-adhesive patch DIA Patch  to overcome the problems associated with the daily oral administration of the drug. The patches were prepared by solvent casting method using acrylate emulsion polymers like covinax 525-78, mowinyl 461 and novacryl PSR32 which served as sustained release matrix polymer and adhesive. Methocel K-15M was added as a solubilizer whereas transcutol, oleic acid and isopropyl myristate were tried as permeation enhancers for the drug-in-adhesive patch. The combination of mowinyl-isopropyl myristate patch was further optimized by 32 factorial design to study the effect of two independent variables i.e. concentration of solubilizer and permeation enhancer on responses i.e. drug release, tensile strength and peel adhesion strength. The formulation was further evaluated for its lipid lowering activity and skin irritation index. The  cumulative release of drug at the end of 24 h was found to be 87.74. The formulation shows tensile strength of 12.75 kgcm2 and peel adhesion strength of 32.44 N25 mm. The Primary irritation index PII for DIA patch was found to be 0.22. The fluvastatin sodium loaded DIA patch significantly inhibits serum cholesterol and triglyceride levels as compared to oral control p0.01 in triton WR 1339 induced hyperlipidemic rat. Hence the developed transdermal patch could be acceptable for transdermal use.

 Current investigation is aimed at designing a fluvastatin sodium loaded drug-in-adhesive patch DIA Patch  to overcome the problems associated with the daily oral administration of the drug. The patches were prepared by solvent casting method using acrylate emulsion polymers like covinax 525-78, mowinyl 461 and novacryl PSR32 which served as sustained release matrix polymer and adhesive. Methocel K-15M was added as a solubilizer whereas transcutol, oleic acid and isopropyl myristate were tried as permeation enhancers for the drug-in-adhesive patch. The combination of mowinyl-isopropyl myristate patch was further optimized by 32 factorial design to study the effect of two independent variables i.e. concentration of solubilizer and permeation enhancer on responses i.e. drug release, tensile strength and peel adhesion strength. The formulation was further evaluated for its lipid lowering activity and skin irritation index. The  cumulative release of drug at the end of 24 h was found to be 87.74. The formulation shows tensile strength of 12.75 kgcm2 and peel adhesion strength of 32.44 N25 mm. The Primary irritation index PII for DIA patch was found to be 0.22. The fluvastatin sodium loaded DIA patch significantly inhibits serum cholesterol and triglyceride levels as compared to oral control p0.01 in triton WR 1339 induced hyperlipidemic rat. Hence the developed transdermal patch could be acceptable for transdermal use.

 Current investigation is aimed at designing a fluvastatin sodium loaded drug-in-adhesive patch DIA Patch  to overcome the problems associated with the daily oral administration of the drug. The patches were prepared by solvent casting method using acrylate emulsion polymers like covinax 525-78, mowinyl 461 and novacryl PSR32 which served as sustained release matrix polymer and adhesive. Methocel K-15M was added as a solubilizer whereas transcutol, oleic acid and isopropyl myristate were tried as permeation enhancers for the drug-in-adhesive patch. The combination of mowinyl-isopropyl myristate patch was further optimized by 32 factorial design to study the effect of two independent variables i.e. concentration of solubilizer and permeation enhancer on responses i.e. drug release, tensile strength and peel adhesion strength. The formulation was further evaluated for its lipid lowering activity and skin irritation index. The  cumulative release of drug at the end of 24 h was found to be 87.74. The formulation shows tensile strength of 12.75 kgcm2 and peel adhesion strength of 32.44 N25 mm. The Primary irritation index PII for DIA patch was found to be 0.22. The fluvastatin sodium loaded DIA patch significantly inhibits serum cholesterol and triglyceride levels as compared to oral control p0.01 in triton WR 1339 induced hyperlipidemic rat. Hence the developed transdermal patch could be acceptable for transdermal use.

Article Details

Formulation and evaluation of fluvastatin sodium drugin-adhesive transdermal system

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.24 Issue 4, pp.562-571

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347943

pISSN:

2630-6344

Pressure-sensitive–adhesive

fluvastatin sodium

drug-in-adhesive patch

% cumulative release

peel adhesion strength

total cholesterol

Issues

Article Details

Formulation and evaluation of fluvastatin sodium drugin-adhesive transdermal system

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.24 Issue 4, pp.562-571

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001347943

pISSN: 2630-6344

Pressure-sensitive–adhesive

fluvastatin sodium

drug-in-adhesive patch

% cumulative release

peel adhesion strength

total cholesterol

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.24 Issue 4, pp.562-571

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347943

pISSN:

2630-6344