Evaluation of metabolic parameters of microsatellites stable and instable colorectal cancer patients via PET/CT

Şadiye Altun Tuzcu; İlbey Erkin Çetin; Fatih Güzel; Erdal Çetinkaya; Bekir Taşdemir; Hüseyin Büyükbayram

Article Details

Evaluation of metabolic parameters of microsatellites stable and instable colorectal cancer patients via PET/CT

Authors:

Şadiye Altun Tuzcu | İlbey Erkin Çetin | Fatih Güzel | Erdal Çetinkaya | Bekir Taşdemir | Hüseyin Büyükbayram

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Nükleer Tıp

Journal:

Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.124-128

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316671

pISSN:

2717-7505

Keywords:

Abstract:

 Aims: Microsatellite instability has been determined as an important indicator in selecting chemotherapy drugs in colorectal cancer. Within the scope of this research, we aimed to elucidate the pathology reports and determine whether the metabolic parameters detected by PETCT differ in MSI-positive and negative patients. Methods: A total of 35 patients were analyzed retrospectively. The patient population consisted of patients who applied to the Nuclear Medicine Department with a diagnosis of colon or rectum cancer, underwent PETCT imaging for staging purposes, and were operated on. Results: A total of 35 colon or rectum cancer patients were included in this retrospective analysis. When microsatellite instability was analyzed among the patients, it was found that female patients comprised 4 microsatellite instability-positive and 16 microsatellite instability-negative individuals. On the other hand, 5 of the males were microsatellite instability positive, and 10 were microsatellite instability negative. The mean SUVmax value was 16.48.2, SUVmean was 8.11.9, TLG was 392.4520.8, and MTV was 26.525.4 in the microsatellite instability-positive individuals. On the other hand, the mean SUVmax value was 22.79.7, SUVmean was 5.22.2, TLG was 316.4325.7, and MTV was 21.721.7 in the microsatellite instability-negative individuals. Conclusion: With the advancement of image analysis technology, MTV, and TLG, volumetric indexes derived from 18F-FDG PET have been proposed for risk stratification of cancer patients. Regarding the outcomes of this research, the semiquantitative and metabolic parameters obtained by PETCT are not different in colorectal cancer cases with instable and stable microsatellites.

 Aims: Microsatellite instability has been determined as an important indicator in selecting chemotherapy drugs in colorectal cancer. Within the scope of this research, we aimed to elucidate the pathology reports and determine whether the metabolic parameters detected by PETCT differ in MSI-positive and negative patients. Methods: A total of 35 patients were analyzed retrospectively. The patient population consisted of patients who applied to the Nuclear Medicine Department with a diagnosis of colon or rectum cancer, underwent PETCT imaging for staging purposes, and were operated on. Results: A total of 35 colon or rectum cancer patients were included in this retrospective analysis. When microsatellite instability was analyzed among the patients, it was found that female patients comprised 4 microsatellite instability-positive and 16 microsatellite instability-negative individuals. On the other hand, 5 of the males were microsatellite instability positive, and 10 were microsatellite instability negative. The mean SUVmax value was 16.48.2, SUVmean was 8.11.9, TLG was 392.4520.8, and MTV was 26.525.4 in the microsatellite instability-positive individuals. On the other hand, the mean SUVmax value was 22.79.7, SUVmean was 5.22.2, TLG was 316.4325.7, and MTV was 21.721.7 in the microsatellite instability-negative individuals. Conclusion: With the advancement of image analysis technology, MTV, and TLG, volumetric indexes derived from 18F-FDG PET have been proposed for risk stratification of cancer patients. Regarding the outcomes of this research, the semiquantitative and metabolic parameters obtained by PETCT are not different in colorectal cancer cases with instable and stable microsatellites.

 Aims: Microsatellite instability has been determined as an important indicator in selecting chemotherapy drugs in colorectal cancer. Within the scope of this research, we aimed to elucidate the pathology reports and determine whether the metabolic parameters detected by PETCT differ in MSI-positive and negative patients. Methods: A total of 35 patients were analyzed retrospectively. The patient population consisted of patients who applied to the Nuclear Medicine Department with a diagnosis of colon or rectum cancer, underwent PETCT imaging for staging purposes, and were operated on. Results: A total of 35 colon or rectum cancer patients were included in this retrospective analysis. When microsatellite instability was analyzed among the patients, it was found that female patients comprised 4 microsatellite instability-positive and 16 microsatellite instability-negative individuals. On the other hand, 5 of the males were microsatellite instability positive, and 10 were microsatellite instability negative. The mean SUVmax value was 16.48.2, SUVmean was 8.11.9, TLG was 392.4520.8, and MTV was 26.525.4 in the microsatellite instability-positive individuals. On the other hand, the mean SUVmax value was 22.79.7, SUVmean was 5.22.2, TLG was 316.4325.7, and MTV was 21.721.7 in the microsatellite instability-negative individuals. Conclusion: With the advancement of image analysis technology, MTV, and TLG, volumetric indexes derived from 18F-FDG PET have been proposed for risk stratification of cancer patients. Regarding the outcomes of this research, the semiquantitative and metabolic parameters obtained by PETCT are not different in colorectal cancer cases with instable and stable microsatellites.

 ÖZET Amaç: Mikrosatellit instabilitesi kolorektal kanserde kemoterapi ilaçlarının seçiminde önemli bir gösterge olarak belirlenmiştir. Bu araştırma kapsamında MSI pozitif ve negatif hastalarda patoloji raporlarının aydınlatılması ve PETBT ile tespit edilen metabolik parametrelerin farklılık gösterip göstermediğinin belirlenmesi amaçlandı. Yöntem: Toplam 35 hasta retrospektif olarak incelendi. Hasta popülasyonunu Nükleer Tıp Anabilim Dalına kolon veya rektum kanseri tanısıyla başvuran, evreleme amacıyla PETBT görüntülemesi yapılan ve ameliyat edilen hastalardan oluştu. Bulgular: Bu retrospektif analize toplam 35 kolon veya rektum kanseri hastası dahil edildi. Hastalar arasında mikrosatellit instabilitesi incelendiğinde, kadın hastaların 4ünün mikrosatellit instabilitesi pozitif, 16sının ise mikrosatellit instabilitesi negatif bireyden oluştuğu görüldü. Öte yandan erkeklerin 5i mikro uydu kararsızlığı pozitif, 10u ise mikro uydu kararsızlığı negatifti. Mikrosatellit instabilitesi pozitif olan bireylerde ortalama SUVmax değeri 16,48,2, SUVort değeri 8,11,9, TLG 392,4520,8 ve MTV 26,525,4 olarak belirlendi. Mikrosatellit instabilitesi negatif olan bireylerde ise ortalama SUVmax değeri 22,79,7, SUVmean değeri 5,22,2, TLG 316,4325,7 ve MTV 21,721,7 olarak belirlendi. Sonuç: Görüntüleme analiz teknolojisinin, MTV ve TLGnin gelişmesiyle birlikte, kanser hastalarının risk sınıflandırması için 18F-FDG PETten türetilen hacimsel indeksler önerilmiştir. Bu araştırmanın sonuçlarına göre, instabil ve stabil mikrosatellitlere sahip kolorektal kanser vakalarında PETBT ile elde edilen yarı kantitatif ve metabolik parametreler farklı değildir.

Article Details

Evaluation of metabolic parameters of microsatellites stable and instable colorectal cancer patients via PET/CT

Authors:

Şadiye Altun Tuzcu | İlbey Erkin Çetin | Fatih Güzel | Erdal Çetinkaya | Bekir Taşdemir | Hüseyin Büyükbayram

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Nükleer Tıp

Journal:

Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.124-128

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316671

pISSN:

2717-7505

Colorectal cancer

microsatellite instability

Positron Emission Tomography/Computed Tomography (PET/CT)

mismatch repair genes (MMR)

standardized uptake value (SUV)Kolorektal kanser

mikrosatellit instabilitesi

Pozitron Emisyon Tomografisi/Bilgisayarlı Tomografi (PET/CT)

uyumsuzluk onarım genleri (MMR)

standartlaştırılmış alım değeri (SUV)

Issues

Article Details

Authors: Şadiye Altun Tuzcu | İlbey Erkin Çetin | Fatih Güzel | Erdal Çetinkaya | Bekir Taşdemir | Hüseyin Büyükbayram

Publisher: MediHealth Academy Yayıncılık

Main Topics: Nükleer Tıp

Journal: Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.124-128

Document Type: Article

Publication Date: 4/2024

Document Language: English

Document ID (Org No.): 2001316671

pISSN: 2717-7505

Issues

Authors:

Şadiye Altun Tuzcu | İlbey Erkin Çetin | Fatih Güzel | Erdal Çetinkaya | Bekir Taşdemir | Hüseyin Büyükbayram

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Nükleer Tıp

Journal:

Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.124-128

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316671

pISSN:

2717-7505